三叶青低聚糖对小鼠胃肠道功能的影响
Effect of Radix Tetrastigma hemsleyanum Oligosaccharides on Gastrointestinal Tract of Experimental Mice
摘要: 目的：探究三叶青低聚糖对小鼠胃肠道功能的影响。方法：50只ICR小鼠随机分为正常组、模型组、三叶青低聚糖低、中、高剂量组，除正常组和模型组灌胃生理盐水外，其余各组按剂量灌胃三叶青低聚糖。观察不同剂量三叶青低聚糖对正常状态下小鼠排便功能、小肠推进率、胃残留率和盐酸洛哌丁胺所致暂时性便秘小鼠排便功能的影响。结果：与正常组和模型组相比较，低、高剂量的三叶青低聚糖可显著缩短正常小鼠和便秘模型小鼠首次排便时间，增加小鼠黑便粒数和黑便水分含量(P < 0.05)；不同剂量三叶青低聚糖均可显著增加正常小鼠的小肠推进率并降低胃残留率(P < 0.05)，且对小鼠的正常生长无明显影响。结论：三叶青低聚糖具有通便作用，并可促进小鼠小肠推进和胃排空。
Abstract: Objective: To investigate the effect of Radix Tetrastigma hemsleyanum oligosaccharides on gastro-intestinal function in mice. Methods: 50 mice of ICR species were randomly divided into 5 groups: blank control group, model group, Radix Tetrastigma hemsleyanum oligosaccharides with low, middle and high dose group. Except the blank control group and the model group which were given physiological saline, the rest of the group were gavaged the different doses of Tetrastigma hemsleyanum oligosaccharides. We observe the effect of different doses of Tetrastigma hemsleyanum oligosaccharides on defecation function, small intestine propulsion rate, gastric residual rate and defecation function of temporary constipation mice induced by loperamide hydrochloride in normal condition. Results: Compared with the normal group and the model group, low and high doses of Tetrastigma hemsleyanum oligosaccharides can significantly shorten the normal mice and constipation model mice first defecation time, increasing the number of mice black particles and melena water content (P < 0.05). All doses of Tetrastigma hemsleyanum oligosaccharides significantly increased the small intestine propulsion rate and gastric residual rate (P < 0.05) in normal mice, and had no significant effect on body weight and organ index (P > 0.05). Conclusion: Tetrastigma hemsleyanum oligosaccharides can improve defecation, and promote intestinal propulsion and gastric emptying in mice.
文章引用：李昶, 姚玥, 万嘉洋, 黄晓娟, 周芳美, 丁志山. 三叶青低聚糖对小鼠胃肠道功能的影响[J]. 药物资讯, 2018, 7(5): 91-96. https://doi.org/10.12677/PI.2018.75017

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