miRNAs在精神分裂症临床诊断及预后中的研究进展
The Diagnosis and Prognosis Research Pro-gress of miRNAs in Schizophrenia
DOI: 10.12677/ACM.2018.87104, PDF,   
作者: 石丛丛, 李 静, 杨丽敏:山东省精神卫生中心三病房,山东 济南
关键词: 微小RNA精神分裂症早期诊断预后MiRNA Schizophrenia Early Diagnosis Prognosis
摘要: 精神分裂症是目前世界上让患者家庭承受最重的经济负担疾病之一,缺乏有效的分子标志物对其进行早期诊断及预后监测。微小RNA (miRNA)是一类约19至25个碱基长度的内源性非编码单链小分子RNA,转录后水平影响基因表达。有研究指出,miRNA在精神分裂症的发生、发展中起到重要作用,从而说明miRNA有可能作成为诊断和监测精神分裂症的预后新型分子标志物及新靶点。本文主要从以下三个方面简述miRNA与精神分裂症密切关系,并展望将来在临床的应用。
Abstract: Schizophrenia is one of the most economically burdened diseases in the world for patients and families. There are no effective molecular markers for early diagnosis and prognosis monitoring. Micro RNAs (miRNAs) are a class of endogenous non-coding single-stranded small RNAs of about 19 to 25 bases in length whose expression is affected by post-transcriptional levels. Previous studies have shown that miRNAs are closely related to the occurrence and development of schizophrenia, suggesting that miRNAs can be used as novel molecular markers for early diagnosis and prognosis monitoring of schizophrenia as well as new targets for molecular therapy. This paper systematically elucidates the mechanisms related to miRNA and schizophrenia from these three aspects, and looks forward to its clinical application.
文章引用:石丛丛, 李静, 杨丽敏. miRNAs在精神分裂症临床诊断及预后中的研究进展[J]. 临床医学进展, 2018, 8(7): 622-626. https://doi.org/10.12677/ACM.2018.87104

参考文献

[1] Perkins, D.O., Jeffries, C.D., Jarskog, L.F., et al. (2013) Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of Risk Loci with Shared Effects on Five Major Psychiatric Disorders: A Genome-Wide Analysis. Lancet, 381, 1371-1379.
[2] Schreiber, R. and Newman-Tancredi, A. (2014) Improving Cognition in Schizophrenia with Antipsychotics that Elicit Neurogenesis through 5-HT(1A) Receptor Activation. Neurobiology of Learning and Memory, 110, 72-80.
[3] Sandoval, J., Díaz-Lagares, A., Salgado, R., et al. (2015) MicroRNA Expression Profiling and DNA Methylation Signature Forderegulated MicroRNA in Cutaneous T-Cell Lymphom. Journal of Investigative Dermatology, 135, 1128-1137.
[4] Pedroza-Torres, A., López-Urrutia, E., García-Castillo, V., et al. (2014) MicroRNAs in Cervical Cancer: Evidences for a miRNA Profile Deregulated by HPV and Its Impact on Radio-Resistance. Molecules, 19, 6263-6281. [Google Scholar] [CrossRef] [PubMed]
[5] Shi, Y., Zhao, X., Hsieh, J., et al. (2010) MicroRNA Regulation of Neural Stem Cells and Neurogenesis. Journal of Neuroscience, 30, 14931-14936.
[6] Lang, M.F. and Shi, Y. (2012) Dynamic Roles of MicroRNAs in Neurogenesis. Frontiers in Neuroscience, 6, 71.
[7] Miller, B.H., Zeier, Z., Xi, L., et al. (2012) MicroRNA-132 Dysregulation in Schizophrenia Has Implications for Both Neurodevelopment and Adult Brain Function. Proceedings of the National Academy of Sciences of the United States of America, 109, 3125-3130.
[8] Santarelli, D.M., Beveridge, N.J., Tooney, P.A., et al. (2011) Upregulation of Dicer and MicroRNA Expression in the Dorsolateral Prefrontal Cortex Brodmann Area 46 in Schizophrenia. Biological Psychiatry, 69, 180-187. [Google Scholar] [CrossRef] [PubMed]
[9] Wong, J., Duncan, C.E., Beveridge, N.J., et al. (2013) Ex-pression of NPAS3 in the Human Cortex and Evidence of Its Posttranscriptional Regulation by miR-17 During Devel-opment, with Implications for Schizophrenia. Schizophrenia Bulletin, 39, 396-406. [Google Scholar] [CrossRef] [PubMed]
[10] Lett, T.A., Chakavarty, M.M., Felsky, D., et al. (2013) The Ge-nome-Wide Supported MicroRNA-137 Variant Predicts Phenotypic Heterogeneity within Schizophrenia. Molecular Psychiatry, 18, 443-450.
[11] Fujiwara, T., Uotani, K., Yoshida, A., et al. (2017) Clinical Significance of Circulating miR-25-3p as A Novel Diagnostic and Prognostic Biomarker in Osteosarcoma. Oncotarget, 8, 33375.
[12] Sita-Lumsden, A.R., Leach, D., Zivi, A., et al. (2017) A Circulating miRNA Signature to Help Prognos-ticate at Prostate Cancer Diagnosis. Journal of Clinical Oncology, 35, 108.
[13] Yokoi, A., Yoshioka, Y., Hirakawa, A., et al. (2017) A Combination of Circulating miRNAs for the Early Detection of Ovarian Cancer. Oncotarget, 8, 89-93.
[14] Santangelo, A., Imbruce, P., Gardenghi, B.A., et al. (2018) A MicroRNA Signature from Serum Exosomes of Patients with Glioma as Complementary Diagnostic Biomarker. Journal of Neuro-Oncology, 136, 51.
[15] Glinsky, Z.Z., Xi, L., et al. (2012) MicroRNA-132 Dysregulation in Schizophrenia Has Implications for Both Neurodevelopment and Adult Brain Function. Proceedings of the National Academy of Sciences of the United States of America, 109, 3125-3130.
[16] Liu, B., Qu, J., Xu, F., et al. (2015) MiR-195 Suppresses Non-Small Cell Lung Cancer By-Targeting CHEK1. Oncotarget, 6, 9445-9456. [Google Scholar] [CrossRef] [PubMed]
[17] Libman-Sokolowska, M., Drozdowicz, E. and Nasierowski, T. (2015) BDNF as a Biomarker in the Course and Treatment of Schizophrenia. Psychiatria Polska, 49, 1149-1158. [Google Scholar] [CrossRef
[18] Sun, X.Y., Zhang, J., Niu, W., et al. (2015) A Preliminary Analysis of microRNAas Potential Clinical Biomarker for Schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 168, 170-178. [Google Scholar] [CrossRef] [PubMed]
[19] Lennertz, L., Quednow, B.B., Benninghoff, J., et al. (2011) Impact of TCF4 on the Genetics of Schizophrenia. European Archives of Psychiatry and Clinical Neuroscience, 261, S161-S165. [Google Scholar] [CrossRef] [PubMed]
[20] Yan, J.J., Chang, Y., Zhang, Y.N., et al. (2017) miR-195 Inhibits Cell Proliferation via Targeting AEG-1 in Hepatocellular Carcinoma. Oncology Letters, 13, 3118-3126. [Google Scholar] [CrossRef] [PubMed]
[21] Sun, X.Y., Lu, J., Zhang, L., et al. (2015) Aberrant microRNA Expres-sion in Peripheral Plasma and Mononuclear Cells as Specific Blood-Based Biomarkers in Schizophrenia Patients. Journal of Clinical Neuroscience, 22, 570-574. [Google Scholar] [CrossRef] [PubMed]
[22] Chai, C., Song, L.J., Yang, B., et al. (2016) Circulating miR-199a-3p in Plasma and Its Potential Diagnostic and Prognostic Value in Glioma. European Review for Medical and Pharmacological Sciences, 20, 4885.
[23] Chen, J., Yang, L., Wang, X., et al. (2017) Reduced Circulating mi-croRNA-203 Predicts Poor Prognosis for Glioblastoma. Cancer Biomark, 20, 521-526. [Google Scholar] [CrossRef
[24] Huang, Q., Wang, C.J., Hou, Z.M., et al. (2017) Serum microRNA-376 Family as Diagnostic and Prognostic Markers in Human Gliomas. Cancer Biomark, 19, 137-144. [Google Scholar] [CrossRef
[25] Tang, Y., Zhao, S., Wang, J., et al. (2017) Plasma miR-122 as a Po-tential Diagnostic and Prognostic Indicator in Human Glioma. Neurological Sciences, 38, 1087-1092. [Google Scholar] [CrossRef] [PubMed]
[26] Shi, W., Du, J., Qi, Y., et al. (2012) Aberrant Expression of Se-rum miRNAs in Schizophrenia. Journal of Psychiatric Research, 46, 198-204. [Google Scholar] [CrossRef] [PubMed]
[27] Liu, S., Yuan, Y.B., Guan, L.L., et al. (2013) miRNA-365 and miRNA-520c-3p Respond to Risperidone Treatment in First-Episode Schizophrenia after a 1 Year Remission. Chinese Medical Journal, 126, 2676-2680.