甲基强的松龙联合静注人免疫球蛋白治疗小儿重症手足口病的疗效观察

Curative Effect Observation between Different Dose of Methylprednisolone with the Human Immunoglobulin in the Treatment of Children with Severe Hand Foot and Mouth Disease

摘要: 目的：观察不同剂量甲基强的松龙联合丙种免疫球蛋白治疗小儿重症手足口病的临床疗效。方法：研究对象选取100例重症手足口病患儿，根据甲基强的松龙治疗剂量不同，分为大剂量组、小剂量组各50例，对比两组疗效。结果显示两组在总有效率、神经受累时间及住院时间方面并无显著差异(P > 0.05)。但小剂量组在退热时间上明显低于大剂量组(P < 0.05)；结论：甲基强的松龙联合丙种球蛋白治疗重症手足口病的疗效确切，应用不同剂量甲基强的松龙对于神经受累改善及住院时间影响上并无显著差异，但小剂量应用甲基强的松龙则能够有效缩短患儿的发热时间，该治疗方法值得推广。

Abstract: Objective: To compare the clinical efficacy of different doses of methylprednisolone with the human immunoglobulin in the treatment of severe hand foot mouth disease in children. Methods: We selected 100 cases of children with severe hand foot mouth disease, and divided them into large dose group and small dose group with 50 cases in each group on the basis of methylprednisolone usage, both groups were given the human immunoglobulin treatments. Curative effects were compared between the two groups. Results: The neurological involvement time and hospital stays between the two groups were not significant (P > 0.05), but the low dose group was significantly lower than that of high dose group in the febrile time (P < 0.05). Conclusion: Glucocorticoid with the human immunoglobulin in the treatment of severe hand foot mouth disease has definite ther-apeutic effect, but there is no statistic difference in the hospital stays and neurological involvement between the two groups, however, application of small dose of methylprednisolone can effectively shorten the febrile time, which was worthing of clinical promotion and application.