PSP/Reg蛋白家族在慢性胰腺炎中研究进展
Research Progress of PSP/Reg Protein Family in Chronic Pancreatitis
摘要: 胰石蛋白(pancreatic stone protein, PSP)，胰腺炎相关蛋白(pancreatitis-associated protein, PAP)和再生蛋白I (Regenerating protein I, Reg I)先后被独立地发现于胰腺的外分泌和内分泌疾病。随后的研究表明，PSP和RegI是同一种蛋白并且其与PAP属于同一种蛋白家族。PSP/Reg和PAP具有相同的选择性特异性的胰酶切割位点，并被胰酶降解形成不溶性纤维。由于有假说提出PSP具有抑制胰石形成的功能，所以PSP又称为胰石蛋白(lithostathine)。但是胰石蛋白的抑制结石形成的功能受到了质疑。目前大部分研究结果表明PSP对于结石形成具有促进作用，而非抑制。
Abstract: Pancreatic stone protein (PSP), pancreatitis-associated protein (PAP) and Regenerating protein I (Reg I) have been independently found in pancreatic exocrine and endocrine diseases. Subsequent studies showed that PSP and Reg I are the same protein and belong to the same protein family as PAP. PSP/Reg and PAP have the same selective specific tryptic cleavage site and are digested by trypsin to form insoluble fiber. Since there is a hypothesis that PSP has a function of inhibiting pancreatic formation, PSP is also called lithostathine. However, the function of inhibiting stone formation by PSP has been questioned. At present, most studies have shown that PSP has a pro-moting effect on the formation of stones, rather than inhibition.
文章引用：毛佳明, 陈士跃, 刘日. PSP/Reg蛋白家族在慢性胰腺炎中研究进展[J]. 临床医学进展, 2018, 8(7): 644-649. https://doi.org/10.12677/ACM.2018.87108

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