一例猫耵聍腺癌的病理学诊断

A Case of Ceruminous Gland Carcinoma in Cat for Pathological Diagnosis

摘要: 通过临床观察、组织学诊断结合免疫组织化学技术对一例猫外耳道肿瘤进行病理学诊断。本病例为一只20岁家猫，肿瘤发生于左侧外耳道，眼观可见多个肿块，大小不一，颜色呈棕红色、浅棕色和蓝黑色。组织学观察可见三种组织特点，第一种以瘤细胞大量增生，排列杂乱，小叶聚集，炎性浸润为主；第二种与第一种相似，但组织内出血严重；第三种为囊状结构，内含有大量分泌物结晶和巨噬细胞浸润。瘤细胞大小不一，形态多样，核空泡化，核分裂相多见。免疫组织化学PCK与α-SMA染色可知增生的瘤细胞来源于耵聍腺腺上皮，Ki-67表达量 ≥ 30%，可知瘤细胞增殖速度较快。通过以上方法确诊该猫所患为耵聍腺癌。

Abstract: An ear tumor was diagnosed in a 20-year-old domestic cat through clinic observation, histology examination and immunohistochemistry technique. The tumor tissue in the left external auditory canal had multiple lumps with different sizes and colors of brown-red, light-brown and blue-black. Three different histological forms were found under a microscope. The first was the mass proliferation of tumor cells, disordered arrangement, aggregation of lobules, and inflammatory infiltration. The second was similar to the first, but there is severe bleeding in the tissue. And the third was a cystic structure containing a large number of secretory crystals and infiltration of macrophages. The tumor cells were different in size and various in shape, the nuclei are vacuolated, and the mitoses are more frequent. The tumor cells with PCK and α-SMA protein expression showed that the proliferation happened in ceruminous gland, and Ki-67 expression quantity more than 30% showed that the cells proliferated rapidly. The result indicated that the tumor in external auditory canal was ceruminous gland carcinoma.