染色体复杂核型异常及AZF微缺失致男性不育一例分析
A Case Analysis of Chromosome Complex Karyotype Abnormality and AZF Microdeletion Causing Male Infertility
DOI: 10.12677/ACM.2018.89134, PDF,   
作者: 杨丽霞, 陈 坤, 李淑云, 康 茹, 张 帆：山东中医药大学第二附属医院生殖医学科遗传室，山东 济南
关键词: 染色体；复杂核型；AZF；微缺失；男性不育；Chromosome； Complex Karyotype； AZF； Microdeletion； Male Infertility
摘要: 男性不育的影响因素很多，其中遗传因素是引起男性不育的重要原因之一，主要包括染色体结构和数目异常及生精相关基因的异常。本文介绍一例染色体复杂核型异常病例，并进行相关文献复习，提示Y染色体完整性对于保持男性生殖功能的重要性，其结构或数目异常以及相关基因的缺失可导致男性严重的生殖缺陷。
Abstract: Many factors affect male infertility, genetic factors, among which, are one of the important causes, including abnormalities in chromosome structure and number, and abnormalities in genes related to spermatogenesis. This paper analyzes a case of complex karyotype abnormality of chromosomes and reviews related literatures, suggesting that the integrity of Y chromosomes is important for maintaining male reproductive function. The abnormal structure or number and the loss of related genes can lead to severe reproductive defects in males.
文章引用：杨丽霞, 陈坤, 李淑云, 康茹, 张帆. 染色体复杂核型异常及AZF微缺失致男性不育一例分析[J]. 临床医学进展, 2018, 8(9): 804-806. https://doi.org/10.12677/ACM.2018.89134

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