人乳头瘤病毒感染与肺癌关系的研究进展

Advances in the Relationship between Human Papillomavirus Infection and Lung Cancer

摘要: 肺癌是严重危害人类健康的恶性肿瘤，近30年来发病率和死亡率呈直线上升趋势，现已居全球各类恶性肿瘤的首位。传统观念认为吸烟是导致肺癌的主要原因，但上述观点并不能解释15%以上终身不吸烟女性肺癌患者发病原因，并且目前认为至少有50%的非吸烟女性肺癌患者发病原因尚不明确。近年来，随着大量针对亚洲肺癌女性患者研究的开展，人乳头瘤病毒感染与肺癌的相关性逐渐引起研究者重视。本文对近年来HPV和肺癌关系的研究进展作简要综述。

Abstract: Lung cancer is a malignant tumor that seriously endangers human healthy. In the past 30 years, the morbidity and mortality of it have been rising in a straight line. It was considered that smoking is the main cause of lung cancer before, but the above opinion cannot explain the reason of lung cancer in more than 15% of non-smoking female patients. At present, it is still unclear that the cause of about half of non-smoking female patients who have lung cancer. In recent years, with mas-sive of studies on Asian women with lung cancer, the correlation between human papillomavirus in-fection and lung cancer has attracted more and more attention from researchers. This paper briefly reviews the research progress of the relationship between HPV and lung cancer in recent years.