RSI，RFS结合PPI在临床诊断咽喉反流性疾病的研究进展
Advances in Clinical Diagnosis of Laryngopharyngeal Reflux Disease by RSI, RFS and PPI
DOI: 10.12677/ACM.2018.810151, PDF,   
作者: 阮 瑶：南华大学研究生院，湖南 衡阳；应民政：岳阳市二人民医院耳鼻咽喉头颈外科，湖南 岳阳
关键词: 咽喉反流性疾病；反流症状评分表；反流体征评分表；诊断；Laryngopharyngeal Reflux Disease； Reflux Symptom Index； Reflux Findings Score； Diagnosis
摘要: 咽喉反流性疾病是胃内容物(酸和胃酶如胃蛋白酶)反流进入喉咽，导致喉、下咽的相关临床症状。LPRD的诊断和治疗方面的许多问题都被认为是有争议的，包括临床诊断标准。因而需要建立一个明确的诊断方法。目前，反流体征评分表(RFS)，反流症状评分表(RSI)及质子泵抑制剂可以很好地用于诊断喉咽反流性疾病，但它不是金标准。作为临床一线工作者，我们正在努力探测一种特异性诊断LPRD的方法。
Abstract: Laryngopharyngeal reflux disease is the retrograde movement of gastric contents (acid and en-zymes such as pepsin) into the laryngopharynx leading to symptoms referable to the lar-ynx/hypopharynx. Many issues with respect to the diagnosis and treatment of LPRD are considered controversial, including the clinical diagnostic criteria and the studies necessary to establish a diagnosis. At present, RFS, RSI with PPI can be excellently used for diagnosing Laryngopharyngeal reflux disease, but are not the gold standard. As physicians, we are trying to detect an instrument to diagnose LPRD specifically.
文章引用：阮瑶, 应民政. RSI，RFS结合PPI在临床诊断咽喉反流性疾病的研究进展[J]. 临床医学进展, 2018, 8(10): 910-914. https://doi.org/10.12677/ACM.2018.810151

参考文献

[1] Vaezi, M.F. (2005) Therapy Insight: Gastroesophageal Reflux Disease and Laryngopharyngeal Reflux. Nature Reviews Gastroenterology & Hepatology, 2, 595-603. [Google Scholar] [CrossRef] [PubMed]
[2] F Vaezi, M. (2006) Therapy Insight: Gastroesophageal Reflux Disease and Laryngopharyngeal Reflux. Nature Clinical Practice Gastroenterology & Hepatology, 2, 595-603.
[3] Dawood, M. (2018) A Clinical Diagnosis of Laryngopharyngeal Reflux in Patients with Voice Related Problems via Correlation between Reflux Symptoms and Laryngoscopic Findings. 56-60.
[4] Belafsky, P.C., Postma, G.N. and Koufman, J.A. (2010) The Validity and Reliability of the Reflux Finding Score (RFS). Laryngoscope, 111, 1313-1317. [Google Scholar] [CrossRef] [PubMed]
[5] Rees, C.J. and Belafsky, P.C. (2008) Laryngopharyngeal Reflux: Current Concepts in Pathophysiology, Diagnosis, and Treatment. International Journal of Speech-Language Pathology, 10, 245-253. [Google Scholar] [CrossRef] [PubMed]
[6] 李进让, 肖水芳, 李湘平, 等. 咽喉反流性疾病诊断与治疗专家共识(2015年)解读[J]. 中华耳鼻咽喉头颈外科杂志, 2016, 51(5): 327-332.
[7] Lechien, J.R., Huet, K., Khalife, M., et al. (2016) Impact of Laryngopharyngeal Reflux on Subjective and Objective Voice Assessments: A Prospective Study. Journal of Otolaryngology-Head & Neck Surgery, 45, 59. [Google Scholar] [CrossRef] [PubMed]
[8] Chen, M., Hou, C., Chen, T., et al. (2018) Reflux Symptom Index and Reflux Finding Score in 91 Asymptomatic Volunteers. Acta Oto-Laryngologica, 138, 659-663. [Google Scholar] [CrossRef] [PubMed]
[9] Belafsky, P.C., Postma, G.N. and Koufman, J.A. (2002) Validity and Reliability of the Reflux Symptom Index (RSI). Journal of Voice, 16, 274-277. [Google Scholar] [CrossRef] 
[10] 张园园, 胡国华. 咽喉反流的研究进展[J]. 临床耳鼻咽喉头颈外科杂志, 2010, 24(1): 45-47.
[11] Barry, D. and F Vaezi, M. (2010) Laryngopharyngeal Reflux: More Questions than Answers. Cleveland Clinic Journal of Medicine, 77, 327-334. [Google Scholar] [CrossRef] [PubMed]
[12] Ford, C.N. (2005) Evaluation and Management of Laryngopharyngeal Reflux. The Journal of the American Medical Association, 294, 1534-1540. [Google Scholar] [CrossRef] [PubMed]
[13] Sataloff, R.T., Hawkshaw, M.J. and Xu, W. (2014) [Laryngopharyngeal Reflux Disease]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 49, 432-436.
[14] Bhargava, A., Shakeel, M.P., Srivastava, A., et al. (2017) Role of Reflux Symptom Index and Reflux Finding Score in Evaluation of Treatment Outcome in Patients with Laryngopharyngeal Reflux. International Journal of Phonosurgery and Laryngology, 7, 39-43. [Google Scholar] [CrossRef] 
[15] Jaspersen, D., Weber, R., Hammar, C.H., et al. (1996) Effect of Omeprazole on the Course of Associated Esophagitis and Laryngitis. Journal of Gastroenterology, 31, 765-767. [Google Scholar] [CrossRef] 
[16] Leite, L.P., Johnston, B.T. and Castell, D.O. (1994) Omeprazole for the Treatment of Posterior Laryngitis. American Journal of Medicine, 96, 321-326. [Google Scholar] [CrossRef] [PubMed]
[17] Issing, W.J., Karkos, P.D., Perreas, K., et al. (2006) Dual-Probe 24-Hour Ambulatory pH Monitoring for Diagnosis of Laryngopharyngeal Reflux. Journal of Laryngology & Otology, 118, 845-848.
[18] Hanson, D.G., Kamel, P.L. and Kahrilas, P.J. (1995) Outcomes of Antireflux Therapy for the Treatment of Chronic Laryngitis. Annals of Otology, Rhinology & Laryngology, 104, 550-555. [Google Scholar] [CrossRef] [PubMed]
[19] Noordzij, J.P., Khidr, A., Desper, E., et al. (2010) Correlation of pH Probe-Measured Laryngopharyngeal Reflux with Symptoms and Signs of Reflux Laryngitis. Laryngoscope, 112, 2192-2195. [Google Scholar] [CrossRef] [PubMed]
[20] Tauber, S., Gross, M. and Issing, W.J. (2010) Association of Laryngopharyngeal Symptoms with Gastroesophageal Reflux Disease. Laryngoscope, 112, 879-886. [Google Scholar] [CrossRef] [PubMed]
[21] Williams, R.B.H., Szczesniak, M.M., Maclean, J.C., et al. (2004) Predictors of Outcome in an Open Label, Therapeutic Trial of High-Dose Omeprazole in Laryngitis. American Journal of Gastroenterology, 99, 777. [Google Scholar] [CrossRef] [PubMed]
[22] Luo, H., Ma, S., Gao, Y., et al. (2015) The Therapeutic Effect of Proton Pump Inhibitor on Alleviation of Hoarseness Symptoms in Patients with Laryngopharyngeal Reflux. Journal of Clinical Otorhinolaryngology Head & Neck Surgery, 29, 997-1001.
[23] 成雷, 孙凤新, 王涛, 等. 质子泵抑制剂联合胃动力药治疗咽喉反流性疾病临床分析[J]. 中国医学文摘(耳鼻咽喉科学), 2017, 32(6): 339-341.

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