垂盆草有效成分改善肝损伤的作用和机制研究进展
Research Advance in the Effect and Mechanism of Active Compounds of Sedum sarmentosum on Improving Liver Injury
DOI: 10.12677/TCM.2019.81004, PDF,    国家自然科学基金支持
作者: 张一凡, 汤凯悦：上海中医药大学附属龙华医院脾胃病研究所，上海；宋海燕：上海中医药大学附属龙华医院脾胃病研究所，上海；中加联合脾胃病研究中心，上海
关键词: 肝损伤；肝炎；垂盆草；有效成分；Liver Injury； Hepatitis； Sedum sarmentosum； Active Compound
摘要: 肝损伤是多种急慢性肝脏疾病的病变结果，持续的肝脏损害，可造成肝脏纤维化、肝硬化、肝衰竭、甚至肝癌等终末期肝脏病。垂盆草为具有保肝降酶功效的中药药材，在临床应用广泛，用于治疗湿热黄疸、急慢性肝炎等多种肝脏疾病。垂盆草减轻肝损伤作用的有效成分包括垂盆草苷、垂盆草总黄酮、槲皮素、金丝桃苷等，主要通过调节氧化应激、炎症信号通路、糖脂代谢紊乱、星状细胞活化、细胞再生等机制减轻肝损伤。本文就近年来垂盆草及其有效成分改善肝损伤的作用和相关机制进行综述，以期推动新型、有效的、具有明确组分的药物的研发，为临床治疗肝损伤提供更安全有效的制剂和方案。
Abstract: Liver injury is the result of a variety of acute and chronic liver diseases. Persistent liver damage can cause end-stage liver diseases such as liver fibrosis, cirrhosis, liver failure, and even liver cancer. As a traditional Chinese medicine with the function of protecting liver and lowering en-zyme, Sedum sarmentosum is widely used in clinical application to treat many kinds of liver dis-eases, such as damp-heat jaundice, acute and chronic hepatitis. The effective ingredients of Sedum sarmentosum in alleviating liver injury include asioside, Sedum sarmentosum total flavonoids, quercetin, hyperoside, etc. They mainly alleviate liver injury by regulating oxidative stress, inflammatory signaling pathway, disorder of glycolipid metabolism, activation of stellate cells and cell regeneration. In this paper, the effects and mechanisms of Sedum sarmentosum and its active compounds on improving liver injury in recent years were reviewed, in order to be helpful to develop new, effective medicine with defined components for clinical treatment of liver injury.
文章引用：张一凡, 汤凯悦, 宋海燕. 垂盆草有效成分改善肝损伤的作用和机制研究进展[J]. 中医学, 2019, 8(1): 12-18. https://doi.org/10.12677/TCM.2019.81004

参考文献

[1] Asrani, S.K., Devarbhavi, H., Eaton, J., et al. (2018) Burden of Liver Diseases in the World. Journal of Hepatology, 70, 151-171. [Google Scholar] [CrossRef] [PubMed]
[2] 蔡卫民. 肝脏炎症→纤维化→癌轴线分子生物学研究的某些进展[J]. 中华肝脏病杂志, 2009, 17(10): 799-800.
[3] Li, S., Hong, M., Tan, H.Y., et al. (2016) Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases. Oxidative Medicine and Cellular Longevity, 2016, Article ID: 4234061. [Google Scholar] [CrossRef] [PubMed]
[4] Zhao, C.Q., Zhou, Y., Ping, J., et al. (2014) Traditional Chinese Medicine for Treatment of Liver Diseases: Progress, Challenges and Opportunities. Journal of Integrative Medicine, 12, 401-408. [Google Scholar] [CrossRef] 
[5] 赵珂佳, 杨丹红. 垂盆草冲剂治疗非酒精性脂肪性肝病31例观察[J]. 浙江中医杂志, 2015, 50(8): 618.
[6] 杨海燕. 垂盆草冲剂治疗慢性乙肝200例临床观察[J]. 邯郸医学高等专科学校学报, 2005, 18(1): 44.
[7] 董亚男, 陈逸云, 叶青艳, 等. 不同剂型的垂盆草对急性肝损伤大鼠的防治作用[J]. 药物评价研究, 2013, 36(6): 426-430.
[8] 秦枫. 中药免疫抑制活性成分的研究[D]: [硕士学位论文]. 杭州: 浙江大学动物科学学院, 2005.
[9] 诸国华, 周启霆. 垂盆草苷的合成[J]. 药学学报, 1999, 34(1): 38-38.
[10] 龙安予, 郑俊霞, 刘蕊, 等. 垂盆草苷对实验性幼年大鼠肝内胆汁淤积的干预作用[J]. 辽宁医学杂志, 2018(2): 23-25.
[11] Lian, L.H., Jin, X., Wu, Y.L., et al. (2010) Hepatoprotective Effects of Sedum sarmentosum on D-Galactosamine/Lipopolysac Charide-Induced Murine Fulminant Hepatic Failure. Journal of Pharmacological Sciences, 114, 147-157. [Google Scholar] [CrossRef] 
[12] 闫冰, 丁安伟, 张丽, 等. 二至丸提取物对小鼠四氯化碳急性肝损伤的保护作用[J]. 中国中药杂志, 2010, 35(22): 3080-3083.
[13] 潘金火, 潘萍. 垂盆草总黄酮中8种单体成分对肝细胞的保护作用[J]. 中国医院药学杂志, 2010, 30(19): 1621-1623.
[14] 潘金火, 潘萍. 垂盆草总黄酮的保肝降酶作用及其化学成分的鉴别研究[J]. 时珍国医国药, 2010, 21(8): 1930-1934.
[15] 蒋志涛, 王雪, 王建春, 等. 垂盆草总黄酮及异鼠李素对对乙酰氨基酚诱导的L02细胞损伤的保护作用[J]. 中国实验方剂学杂志, 2018, 24(6): 121-125.
[16] 林远灿, 骆海莺. 垂盆草总黄酮对实验性肝纤维化干预作用的研究[J]. 中华中医药学刊, 2015, 33(8): 1962-1964.
[17] 林远灿, 骆海莺, 金乾兴, 等. 垂盆草总黄酮影响肝星状细胞凋亡的作用机制研究[J]. 中国中药杂志, 2015(16): 3273-3277.
[18] 辛秀, 袁琳, 王兴, 等. 槲皮素对肝脏的药理作用研究进展[J]. 中国中医药信息杂志, 2008, 15(S1): 102-104.
[19] 苏俊锋, 郭长江. 食物黄酮槲皮素的抗氧化作用[J]. 解放军预防医学杂志, 2001, 19(3): 229-231.
[20] Atef, Y., El-Fayoumi, H.M., Abdel-Mottaleb, Y., et al. (2017) Quercetin and Tin Protoporphyrin Attenuate Hepatic Ischemia Reperfusion Injury: Role of HO-1. Naunyn-Schmiedeberg’s Archives of Pharmacology, 390, 871-881. [Google Scholar] [CrossRef] [PubMed]
[21] Wu, L., Zhang, Q., Dai, W., et al. (2017) Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-κB Pathway. Gastroenterology Research and Practice, 2017, 1-15. [Google Scholar] [CrossRef] [PubMed]
[22] 沈钦海, 秦召敏, 刘丽, 等. 槲皮素对肝细胞氧化应激损伤的保护作用[J]. 天津医药, 2015, 43(10): 1100-1103.
[23] 刘爽, 姚平, 李珂, 等. 槲皮素对大鼠原代肝细胞酒精性氧化损伤的防护作用[J]. 营养学报, 2007, 29(3): 288-291.
[24] 邓玥, 揭琴丰, 郝丽萍, 等. 槲皮素通过促进Nrf2转位拮抗人肝细胞酒精性氧化损伤[J]. 营养学报, 2010, 32(6): 532-535.
[25] 魏彩冰, 周莲娣, 张育珍, 等. 槲皮素通过核因子E2相关因子/抗氧化应答元件(Nrf2/ARE)信号通路发挥对免疫性肝损伤的保护作用[J]. 细胞与分子免疫学杂志, 2017, 33(3): 300-304.
[26] 张超, 李昌平, 聂娇. 槲皮素对非酒精性脂肪肝模型大鼠硬脂酰辅酶A去饱和酶1和肝X受体α表达的影响[J]. 中国药理学与毒理学杂志, 2017(8): 807-814.
[27] 白纪红, 梁志清, 秦青, 等. 槲皮素对非酒精性脂肪肝大鼠血清IL-18和IL-10的影响[J]. 中药药理与临床, 2013, 29(1): 54-56.
[28] Li, S., Cao, H., Shen, D., et al. (2018) Quercetin Protects against ox-LDL-Induced Injury via Regulation of ABCAl, LXR-α and PCSK9 in RAW264.7 Macrophages. Molecular Medicine Reports, 18, 799-806. [Google Scholar] [CrossRef] [PubMed]
[29] Peng, J., Li, Q., Li, K., et al. (2017) Quercetin Improves Glucose and Lipid Metabolism of Diabetic Rats: Involvement of Akt Signaling and SIRT1. Journal of Diabetes Research, 2017, 1-10. [Google Scholar] [CrossRef] [PubMed]
[30] Yu, X., Xu, Y., Zhang, S., et al. (2016) Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy. Nutrients, 8, 27-40. [Google Scholar] [CrossRef] [PubMed]
[31] Wang, R., Zhang, H., Wang, Y., et al. (2017) Inhibitory Effects of Quercetin on the Progression of Liver Fibrosis through the Regulation of NF-кB/IкBα, p38 MAPK, and Bcl-2/Bax Signaling. International Immunopharmacology, 6, 126-133. [Google Scholar] [CrossRef] [PubMed]
[32] Kang, L.P., Qi, L.H., Zhang, J.P., et al. (2001) Effect of Genistein and Quercetin on Proliferation, Collagen Synthesis, and Type I Procollagen mRNA Levels of Rat Hepatic Stellate Cells. Acta Pharmacologica Sinica, 22, 793-796.
[33] Wu, L., Zhang, Q., Mo, W., et al. (2017) Quercetin Prevents Hepatic Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Reducing Autophagy via the TGF-β1/Smads and PI3K/Akt Pathways. Scientific Reports, 7, 9289-9320. [Google Scholar] [CrossRef] [PubMed]
[34] 李中, 史霖, 杨建会, 等. 槲皮素对三硝基甲苯染毒小鼠肝脏病理形态学的影响[J]. 中国工业医学杂志, 1999(2): 88-90.
[35] Peng, Z., Gong, X., Yang, Y., et al. (2017) Hepatoprotective Effect of Quercetin against LPS/d-GalN Induced Acute Liver Injury in Mice by Inhibiting the IKK/NF-κB and MAPK Signal Pathways. International Immunopharmacology, 11, 281-289. [Google Scholar] [CrossRef] [PubMed]
[36] 翁书强, 姚群燕, 李希, 等. 槲皮素对刀豆蛋白A诱导小鼠急性肝损伤的保护作用[J]. 胃肠病学和肝病学杂志, 2015, 24(1): 40-44.
[37] Liu, S., Tian, L., Chai, G., et al. (2018) Targeting Heme Oxygenase-1 by Quercetin Ameliorates Alcohol-Induced Acute Liver Injury via Inhibiting NLRP3 Inflammasome Activation. Food & Function, 9, 4184-4193. [Google Scholar] [CrossRef] 
[38] Zhu, M., Zhou, X. and Zhao, J. (2017) Quercetin Prevents Alco-hol-Induced Liver Injury through Targeting of PI3K/Akt/Nuclear Factor-κB and STAT3 Signaling Pathway. Experimental & Therapeutic Medicine, 14, 6169-6190. [Google Scholar] [CrossRef] [PubMed]
[39] 朱玉婷, 邢同岳, 毛海芬, 等. 槲皮素对高糖诱导的原代小胶质细胞炎性反应的抑制作用[J]. 中国医院药学杂志, 2013, 33(21): 1787-1790.
[40] 刘英娟, 申玉金, 杜金梁, 等. 槲皮素对四氯化碳致建鲤肝细胞损伤的保护作用[J]. 农业生物技术学报, 2015, 23(3): 369-379.
[41] Wei, C.B., Tao, K., Jiang, R., et al. (2017) Quercetin Protects Mouse Liver against Triptolide-Induced Hepatic Injury by Restoring Th17/Treg Balance through Tim-3 and TLR4-MyD88-NF-κB Pathway. International Immunopharma-cology, 53, 73-82. [Google Scholar] [CrossRef] [PubMed]
[42] Wei, C., Zhou, L., Zhang, Y., et al. (2017) Protective Effect of Quercetin against Immunological Liver Injury through Activating Nrf2/ARE Signaling Pathway. Chinese Journal of Cellular and Molecular Immunology, 33, 300-304.
[43] Kemelo, M.K., Pierzynová, A., Kutinová, C.N., et al. (2017) The Involvement of Sirtuin 1 and Heme Oxygenase 1 in the Hepatoprotective Effects of Quercetin against Carbon Tetrachloride-Induced Sub-Chronic Liver Toxicity in Rats. Chemico-Biological Interactions, 269, 1-8. [Google Scholar] [CrossRef] [PubMed]
[44] 黄凯, 杨新波, 黄正明, 等. 金丝桃苷药理作用研究进展[J]. 医药导报, 2009, 28(8): 1046-1048.
[45] 黄凯, 耿淼, 王建华, 等. 金丝桃苷对免疫性肝损伤小鼠的保护作用[J]. 中国实验方剂学杂志, 2015(19): 137-141.
[46] 黄明春, 陈剑鸿, 胡小刚, 等. 金丝桃苷对CCl4诱导大鼠急性肝损伤抗氧化应激研究[J]. 局解手术学杂志, 2013(6): 588-590.
[47] 乔靖怡, 汪保英, 栗俞程, 等. 金丝桃苷对小鼠急性酒精性肝损伤的保护作用[J]. 中药药理与临床, 2017(3): 30-33.
[48] Xing, H.Y., Liu, Y., Chen, J.H., et al. (2011) Hyperoside Attenuates Hydrogen Peroxide-Induced L02 Cell Damage via MAPK-Dependent Keap(1)-Nrf(2)-ARE Signaling Pathway. Biochemical and Biophysical Research Communications, 410, 759-765. [Google Scholar] [CrossRef] [PubMed]