重复经颅磁刺激联合草酸艾司西酞普兰对卒中后抑郁伴睡眠障碍的疗效观察

Effect of Repeated Transcranial Magnetic Stimulation Combined with Oxalate Aisixitaipulan on Depression and Sleep Disturbance after Stroke

摘要: 目的：探讨重复经颅磁刺激(Repeated transcranial magnetic stimulation rTMS)联合草酸艾司西酞普兰对卒中后抑郁(post-stroke depression PSD)伴睡眠障碍的疗效。方法：选取我院2017年12月至2018年11月被确诊为PSD伴睡眠障碍的患者100例，采用数字法随机分为两组，实验组50例，给予卒中常规治疗 + rTMS (连续刺激15 min/次，qd) + 草酸艾司西酞普兰。对照组50例，给予卒中常规治疗+草酸艾司西酞普兰。分别于治疗前后采用汉密顿抑郁量表(HAMD)、匹兹堡睡眠指数(PSQI)测评其症状改善情况。结果：经治疗，两组患者，HAMD、PSQI量表评分较治疗前均降低，p < 0.05，具有统计学差异。结论：rTMS对PSD患者患者较好的改善抑郁水平，提高患者睡眠质量，对PSD抑郁及睡眠改善具有重要临床意义。

Abstract: Objective: To investigate the effect of repeated transcranial magnetic stimulation (repeated tran-scranial magnetic stimulation RTMS) combined with oxalic acid escitalopram phthalocyanine on post-stroke depression (post-stroke depression PSD) with sleep disorder. Methods: 100 patients who were diagnosed with PSD with sleep disorder from January 2018 to November 2018 were randomly divided into two groups by digital method, 50 cases in the experimental group, and +RTMS (continuous stimulation of 15 min/, QD) + oxalic acid escitalopram phthalic plane were given. In the control group, 50 cases were given routine treatment of stroke + oxalic acid escital-opram. The Hamilton Depression Scale (HAMD) and Pittsburg Sleep Index (PSQI) were used to evaluate the improvement of symptoms before and after treatment. Results: After treatment, the scores of the HAMD and PSQI scales were lower than those before treatment, p < 0.05, with statis-tical difference. Conclusion: rTMS has significant clinical effect for PSD patients to improve their depression level and improve their sleep quality.