启动子甲基化通过调节RAGE基因表达影响UC风险
Promoter Methylation Alters the UC Risk by Regulating RAGE Expression
DOI: 10.12677/ACM.2019.91015, PDF,    国家自然科学基金支持
作者: 周玉兰：广东医科大学附属医院临床医学研究中心，广东 湛江；闫守泉, 蔡月清, 苏振演, 王家丰：广东医科大学附属医院干细胞研发与临床转化中心，广东 湛江
关键词: 末端糖基化终末产物受体；溃疡性结肠炎；甲基化；转录；RAGE； UC； Methylation； Transcription
摘要: 末端糖基化终末产物受体基因(RAGE)被证实在多种炎症相关疾病中发挥重要的信号传导作用。最近我们在溃疡性结肠炎(UC)组织样本中发现在RAGE基因启动子区存在一个富含CpG的区域甲基化存在个体差异现象。启动子区高甲基化可能会影响基因的转录过程，因此本研究拟通过病例对照探索RAGE基因启动子区甲基化对其转录水平的影响极其甲基化与UC风险的相关性。研究发现启动子区甲基化程度与转录水平密切相关，该区域可能是调控RAGE基因转录的关键部位。我们的研究为进一步理解UC病变机理开辟新的切入点，同时为UC个性化风险精准预测提供理论基础。
Abstract: Receptor for advanced glycation end products (RAGE) has been shown to play an important role in signal transduction in a variety of inflammation-related diseases. Recently, we found an individual difference of methylation in a CpG-island located in the promoter region of RAGE gene. It has been proved that hypermethylation of promoter region may affect the transcription process of genes. Therefore, this study intends to explore the influence of methylation in promoter region of RAGE gene on its transcription level and the correlation between methylation and UC risk through a case control study. Studies have found that the methylation level of RAGE promoter region is closely related to its transcription level, and the methylation status of RAGE promoter region may be play an important role in regulating the transcription of RAGE genes. Our research opens up a new entry point for further understanding the pathogenesis of UC, and provides a theoretical basis for accurate prediction of personalized UC risk.
文章引用：周玉兰, 闫守泉, 蔡月清, 苏振演, 王家丰. 启动子甲基化通过调节RAGE基因表达影响UC风险[J]. 临床医学进展, 2019, 9(1): 88-95. https://doi.org/10.12677/ACM.2019.91015

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