影响海藻酸钠–丙烯酰胺双网络水凝胶力学性能的制备因素

Preparation Factors Affecting the Mechanical Properties of Sodium Alginate-Acrylamide Double Network Hydrogel

摘要: 水凝胶具有三维交联网络结构和理化性能可调节的特性，在农业抗旱、污染调节、药物输送、组织工程等方面得到了广泛应用，但固有的低机械强度极大地限制了水凝胶的应用，特别是在需要坚硬、坚韧和抗冲击特性的承重软组织中。本文通过海藻酸钠溶液共价网络结合PAM共价网络来构建复合水凝胶，采用简单的浸泡策略，促进海藻酸钠微晶和链缠结网络的形成，将复合水凝胶转化为高机械混合双网络水凝胶。通过改变水凝胶制备过程中的海藻酸钠溶液浓度，交联剂的浓度，引发剂的用量，研究了制备条件对双网络水凝胶力学性能的影响。

Abstract: Hydrogels have three-dimensional crosslinked network structure and tunable physicochemical properties, which have been widely used in agricultural drought resistance, pollution regulation, drug delivery, tissue engineering and other aspects. However, there are few applications of hy-drogels due to the terrible mechanical properties, especially in load-bearing soft tissue with tough, tough and impact-resistant properties. In this paper, a covalent PAM network was synthesized by covalent bonding of sodium alginate solution to construct a composite hydrogel. Then, a simple soaking strategy was used to convert the composite hydrogel into a highly mechanically mixed double network hydrogel through the formation of sodium alginate crystallites and chain tangle networks. The experiment was conducted to control the mechanical properties of hydrogels pre-pared under different conditions by controlling the concentration of sodium alginate solution, the concentration of cross-linking agent, and the amount of initiator used in the hydrogel preparation process.