红花如意丸联用甲硝唑联合治疗慢性盆腔炎的疗效及机制探讨

The Curative Effect and Mechanism of Safflower Wishful Pill and Metronidazole in the Treatment of Chronic Pelvic Inflammatory Disease

摘要: 目的：观察红花如意丸与甲硝唑联合使用治疗慢性盆腔炎的疗效，并对其可能机制作初步探索。方法:从我们医院选取慢性盆腔炎的患者，共计100例，其中对照组(常规治疗 + 甲硝唑)、治疗组(常规治疗 + 甲硝唑 + 红花如意丸)各50例，共治疗3疗程。观察疗效、安全性，并对患者治疗前、后血清中IL-2、IL-4、IL-10、TNF-α及TGF-β1的含量作评价。结果：两组均有一定的疗效，降低VSA评分，缓解疼痛；另外，两组分别与各自治疗前比较，患者血清中IL-2、IL-4、IL-10、TGF-β1的含量均有上升，而TNF-α有下降；两组的治疗后相互比较，则治疗组患者血清中IL-2、IL-4、IL-10、TGF-β1的水平相对更高、TNF-α更低。结论：红花如意丸与甲硝唑联合使用能升高IL-2、IL-4、IL-10、TGF-β1的水平，降低TNF-α的水平，对治疗慢性盆腔炎有不错的临床疗效。

Abstract: AIM: To observe the clinical effect of Saffron wishful pill together with metronidazole on Chronic pelvic inflammatory disease, and explore possible mechanisms. METHODS: Choose 100 cases of the Chronic pelvic inflammatory disease patients from our hospital, and patients were randomly divided into two groups: The control group (conventional treatment + metronidazole), and the treatment group (conventional treatment + metronidazole + safflower wishful pill), with 3 courses of treatment. The curative effect and safety were observed, and the serum levels of IL-2, IL-4, IL-10, TNF-α and TGF-β1 were evaluated before and after treatment. RESULTS: Both groups can reduce VSA score and relieve pain. In addition, the levels of IL-2, IL-4, IL-10 and TGF-β1 in the serum of the two groups were increased compared with those before treatment, and TNF-α decreased. After treatment, the two groups were compared with each other; the serum levels of IL-2, IL-4, IL-10 and TGF-β1 in the treatment group were relatively higher and TNF-α was lower. CONCLUSION: The combination of safflower wishful pill and metronidazole can raise the level of IL-2, IL-4, IL-10 and TGF-β1 and decrease the level of TNF-α, which has a good clinical curative effect in the treatment of chronic pelvic inflammatory disease.