应用奈维加固食管胃吻合口的试验研究

An Experimental Study on Reinforcement of Esophagogastric Anastomosis by Neoveil^®

摘要: 目的：研究应用补片加固食管胃吻合口的效果。方法：选取新鲜离体猪食管及猪胃制作食管胃吻合模型，第一部试验，找到模型承受内部压力时吻合口薄弱点，第二部试验，通过测定爆破压，评价奈维对吻合口薄弱点的加固作用。结果：吻合口薄弱位置位于食管肌层，加奈维组吻合口模型的爆破压高于无奈维加固组的爆破压(P < 0.001)。结论：试验的结果表明，在体外模型中使用奈维可以起到加固吻合口的作用，应用奈维加固吻合口薄弱部位可能减少吻合口瘘的发生。

Abstract: Objective: To study the effect of reinforcement of esophagogastric anastomosis by Neoveil^®. Methods: The esophagogastric anastomosis model was made by fresh isolated pig esophagus and stomach. In Experiment 1, the weak point of the model under internal pressure was clarified; in Experiment 2, we evaluated the effect of using Neoveil^® to reinforce the weak point of the anastomosis by measuring the burst pressure. Results: The weak point of the anastomosis was the esophageal muscular layer; the burst pressure of anastomosis in group with Neoveil^® was significantly higher than the group with no Neoveil^® reinforcement (P < 0.001). Conclusion: These findings suggest that the use of Neoveil^® as a buttressing material can reinforce the anastomosis in this ex vivo model; reinforcement of the weak point of the anastomosis with Neoveil^® may lead to fewer anastomotic leaks.