MicroRNAs调控宿主抗病毒天然免疫的研究进展
Advances in Research on MicroRNAs Regulating Host Antiviral Innate Immunity
DOI: 10.12677/AMB.2019.81003, PDF,  被引量   
作者: 韩婷婷, 郭 乐, 申元英:大理大学基础医学院,云南 大理
关键词: MicroRNA抗病毒天然免疫基因调控MicroRNA Antivirus Natural Immunity Gene Regulation
摘要: MicroRNA (miRNA)是一类长度为19~24个核苷酸的非编码RNA,参与调控细胞的各生理过程。病毒感染宿主后能够诱导细胞内某些miRNAs的表达,这些miRNAs又反过来参与调控宿主的抗病毒天然免疫应答,进而增强宿主抗病毒能力。深入探究miRNAs介导的宿主抗病毒天然免疫过程,对于阐明病毒的致病机理和制定新的基因治疗策略具有深远的意义。
Abstract: MicroRNA (miRNA) is a kind of non-coding RNA with length of 19 - 24 nucleotides, which regulates the physiological processes of cells. Virus infection can induce the expression of some miRNAs in host cells. These miRNAs are involved in regulating the antiviral natural immune response of the host in turn, thereby enhancing the host's antiviral ability. Deeply exploring the natural immune process of host antiviral mediated by miRNAs has far-reaching significance for elucidating the pathogenesis of viruses and formulating new gene therapy strategies.
文章引用:韩婷婷, 郭乐, 申元英. MicroRNAs调控宿主抗病毒天然免疫的研究进展[J]. 微生物前沿, 2019, 8(1): 15-21. https://doi.org/10.12677/AMB.2019.81003

参考文献

[1] Hoffmann, H.-H., Schneider, W.M. and Rice, C.M. (2005) Interferons and Viruses: An Evolutionary Arms Race of Molecular Interactions. Trends in Immunology, 36, 124-138. [Google Scholar] [CrossRef] [PubMed]
[2] Barbalat, R., et al. (2011) Nucleic Acid Recognition by the Innate Immune System. Annual Review of Immunology, 29, 185-214. [Google Scholar] [CrossRef] [PubMed]
[3] Chen, W., et al. (2013) Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation. Cell, 152, 467-478. [Google Scholar] [CrossRef] [PubMed]
[4] Tili, E., Michaille, J.-J. and Calin, G.A. (2008) Expression and Function of Micro-RNAs in Immune Cells during Normal or Disease State. International Journal of Medical Science, 5, 73-79.
[5] Bushati, N. and Cohen, S.M. (2007) MicroRNA Functions. Annual Review of Cell and Developmental Biology, 23, 175-205. [Google Scholar] [CrossRef] [PubMed]
[6] Hou, J., Wang, P., Lin, L., et al. (2009) MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2. The Journal of Immunology, 183, 2150-2158. [Google Scholar] [CrossRef] [PubMed]
[7] Wang, P., Hou, J., Lin, L., et al. (2010) Inducible MicroRNA-155 Feedback Promotes Type I IFN Signaling in Antiviral Innate Immunity by Targeting Suppressor of Cytokine Signaling 1. The Journal of Immunology, 185, 6226-6233. [Google Scholar] [CrossRef] [PubMed]
[8] Lee, R.C., Feinbamn, R.L. and Ambros, V. (1993) The C. elegans Heterochronic Gene Lin-4 Encodes Small RNAs with Antisensecomplementarity to Lin-14. Cell, 75, 843-854. [Google Scholar] [CrossRef
[9] Yanagisawa, N., Takayama, N., Nakayama, E., et al. (2010) Pre-Exposure Intradermal Rabies Vaccination Using Japanese Rabies Vaccine Following WHO Recommended Schedule. Kansenshogaku Zasshi, 84, 313-314.
[10] Lee, Y., Kim, M., Han, J., et al. (2004) MicroRNA Genes Are Transcribedby RNA Ploymer-Ase II. EMBO Journal, 23, 4051-4060. [Google Scholar] [CrossRef] [PubMed]
[11] Khvorova, A., Reynolds, A. and Jayasena, S.D. (2003) Functional SiRNAs and MiRNAs Exhibit Strand Bias. Cell, 115, 209-216. [Google Scholar] [CrossRef
[12] Ambros, V., Lee, R.C., Lavanway, A., et al. (2003) MicroRNAs and Other Tiny Endogenous RNAs in C. elegans. Current Biology, 13, 807-818. [Google Scholar] [CrossRef
[13] Filipowicz, W., Bhattacharyya, S.N. and Sonenberg, N. (2008) Mechanisms of Post-Transcriptional Regulation by MicroRNAs: Are the Answers in Sight? Nature Reviews Genetics, 9, 102. [Google Scholar] [CrossRef] [PubMed]
[14] Sun, K. and Lai, E.C. (2013) Adult-Specific Functions of Animal MicroRNAs. Nature Reviews Genetics, 14, 535-548. [Google Scholar] [CrossRef] [PubMed]
[15] Nakhaei, P., Genin, P., Civas, A. and Hiscott, J. (2009) RIG-I-Like Receptors: Sensing and Responding to RNA Virus Infection. Seminars in Immunology, 21, 215-222. [Google Scholar] [CrossRef] [PubMed]
[16] O’Neill, L.A. and Bowie, A.G. (2007) The Family of Five: TIR-Domain-Containing Adaptors in Toll-Like Receptor Signalling. Nature Reviews Immunology, 7, 353-364. [Google Scholar] [CrossRef] [PubMed]
[17] Gack, M.U., Shin, Y.C., Joo, C.H., et al. (2007) TRIM25 RING-Finger E3 Ubiquitin Ligase Is Essential for RIG-I-Mediated Antiviral Activity. Nature, 446, 916-920. [Google Scholar] [CrossRef] [PubMed]
[18] Barber, G.N. (2001) Host Defense, Viruses and Apoptosis. Cell Death & Differentiation, 8, 113-126. [Google Scholar] [CrossRef] [PubMed]
[19] Zou, W. and Zhang, D.E. (2006) The Interferon-Inducible Ubiquitin-Protein Isopeptide Ligase (E3) EFP Also Functions as an ISG15 E3 Ligase. The Journal of Biological Chemistry, 281, 3989-3994. [Google Scholar] [CrossRef
[20] Lodge, R., Ferreira Barbosa, J.A., Lombard-Vadnais, F., Gilmore, J.C., Deshiere, A., Gosselin, A., et al. (2017) Host microRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor. Cell, 21, 141-153.
[21] Gorbalenya, A.E., Enjuanes, L., Ziebuhr, J. and Snijder, E.J. (2006) Nidovirales: Evolving the Largest RNA Virus Genome. Virus Research, 117, 17-37. [Google Scholar] [CrossRef] [PubMed]
[22] Gao, L., Guo, X.-K., Wang, L., Zhang, Q., Li, N., Chen, X.-X., et al. (2013) MicroRNA 181 Suppresses Porcine Reproductive and Respiratory Syndromevirus (PRRSV) Infection by Targeting PRRSV Receptor CD163. Virology Journal, 87, 8808-8812. [Google Scholar] [CrossRef
[23] Guo, X.-K., Zhang, Q., Gao, L., Li, N., Chen, X.-X. and Feng, W.-H. (2013) Increasing Expression of microRNA 181 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication and Has Implications for Controlling Virus Infection. Virology Journal, 87, 1159-1171. [Google Scholar] [CrossRef
[24] Smith, J.L., Jeng, S., McWeeney, S.K. and Hirsch, A.J. (2017) A microRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection. Virology Journal, 91, e02388.
[25] Gang, X., et al. (2014) MiR-221 Accentuates IFN’s Anti-HCV Effect by Downregulating SOCS1 and SOCS3. Virology Journal, 462-463, 343-350.
[26] Yoshimura, A., Naka, T. and Kubo, M. (2007) SOCS Proteins, Cytokine Signalling and Immune Regulation. Nature Reviews Immunology, 7, 454-465. [Google Scholar] [CrossRef] [PubMed]
[27] Yoshikawa, T., Takata, A., Otsuka, M., et al. (2012) Silencing of microRNA-122 En-hances Interferon—A Signaling in the Liver through Regulating SOCS3 Promoter Methylation. Scientific Reports, 2, 637. [Google Scholar] [CrossRef] [PubMed]
[28] Diosa-Toro, M., Echavarría-Consuegra, L., Flipse, J., Fernández, G.J., Kluiver, J., van den Berg, A., et al. (2017) MicroRNA Profiling of Human Primary Macrophages Exposed to Dengue Virus Identifies miR-NA-3614-5p as Antiviral and Regulator of ADAR1 Expression. PLOS Neglected Tropical Diseases, 11, e0005981. [Google Scholar] [CrossRef] [PubMed]
[29] Tang, W.-F., Huang, R.-T., Chien, K.-Y., Huang, J.-Y., Lau, K.-S., Jheng, J.-R., et al. (2016) Host microRNA miR-197 Plays a Negative Regulatory Role in the Enterovirus 71 Infectious Cycle by Targeting the RAN Protein. Virology Journal, 90, 1424-1438. [Google Scholar] [CrossRef
[30] Chen, Z., Ye, J., Ashraf, U., Li, Y., Wei, S., Wan, S., et al. (2016) MicroRNA-33a-5p Modulates Japanese Encephalitis Virus Replication by Targeting Eukaryotic Translation Elongation Factor 1A1. Virology Journal, 90, 3722-3734. [Google Scholar] [CrossRef
[31] Shim, B.-S., Wu, W., Kyriakis, C.S., Bakre, A., Jorquera, P.A., Perwitasari, O., et al. (2016) MicroRNA-555 Has Potent Antiviral Properties against Poliovirus. Journal of General Virology, 97, 659-668. [Google Scholar] [CrossRef] [PubMed]
[32] Rosenberger, C.M., Podyminogin, R.L., Diercks, A.H., Treuting, P.M., Peschon, J.J., Rodriguez, D., et al. (2017) miR-144 Attenuates the Host Response Toinfluenza Virus by Targeting the TRAF6-IRF7 Signaling Axis. PLOS Pathogens, 13, e1006305. [Google Scholar] [CrossRef] [PubMed]
[33] Fulcher, J.A., Koukos, G., Koutsioumpa, M., et al. (2017) Unique microRNA Expression in the Colonic Mucosa during Chronic HIV-1 Infection. AIDS, 11, 23.
[34] Hazra, B., Kumawat, K.L. and Basu, A. (2017) The Host microRNA miR-301a Blocks the IRF1-Mediated Neuronal Innate Immune Response to Japanese Encephalitis Virus Infection. Science Signaling, 10, eaaf5185.
[35] Chakraborty, C., Sharma, A.R., Sharma, G., Doss, C.G.P. and Lee, S.-S. (2017) Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine. Molecular Therapy—Nucleic Acids, 8, 132-143. [Google Scholar] [CrossRef] [PubMed]
[36] Li, Z. and Rana, T.M. (2014) Therapeutic Targeting of microRNAs: Current Status and Future Challenges. Nature Reviews Drug Discovery, 13, 622-638. [Google Scholar] [CrossRef] [PubMed]
[37] Yang, N. (2015) An Overview of Viral and Nonviral Delivery Systems for microRNA. International Journal of Pharmaceutical Investigation, 5, 179-181. [Google Scholar] [CrossRef
[38] Yang, X., Marcucci, K., Anguela, X., et al. (2013) Preclinical Evaluation of an anti-HCV miRNA Cluster for Treatment of HCV Infection. Molecular Therapy, 21, 588-601. [Google Scholar] [CrossRef] [PubMed]