中西医结合治疗对甲状腺功能低下老龄家兔的血清β-淀粉样蛋白的影响

Effect of Chinese and Western Medicine Combined Treatment on Serum Beta-Amyloid in Elderly Rabbits with Hypothyroidism

摘要: 目的：研究甲状腺激素水平改变对血清β-淀粉样蛋白浓度的影响。方法：模型组家兔给予药物造成对健康家兔正常甲状腺组织的损害，此后给予单纯西医治疗或中西医结合治疗，测量各种治疗对血清β-淀粉样蛋白浓度的影响。结果：单纯西医治疗组血清Aβ浓度变化：血清Aβ浓度于造模后1周开始上升，2~5周升高明显，此后逐渐下降，至治疗后第6个月仍高于造模前水平。中西医结合治疗组血清Aβ浓度变化：血清Aβ浓度于造模后1周开始上升，2~5周升高明显，此后逐渐下降，至治疗后第6个月仍高于造模前水平。结论：单纯补充左甲状腺素钠与中西医结合治疗对甲状腺功能低下老龄家兔血清β-淀粉样蛋白浓度均有降低作用，本次实验中，生效时间为治疗后第3周，显效时间为治疗后4~6个月。但中西医结合治疗后对血清β-淀粉样蛋白浓度的降低作用自造模后第2个月起较单纯西医治疗组明显。

Abstract: Objective: To study the effect of thyroid hormone levels on serum amyloid beta protein concentra-tion. Methods: The model group rabbits were given medicine to cause damage to the normal thyroid tissue of healthy rabbits. After that, they were given western medicine treatment or integrated traditional Chinese and Western medicine treatment, and the effects of various treatments on serum amyloid beta protein concentration were measured. Results: The changes of serum A beta concentration in the simple western medicine treatment group: serum A beta concentration began to rise 1 week after modeling, increased significantly at 2~5 weeks, and then gradually decreased, and to six months after treatment was still higher than the pre-modeling level. The changes of se-rum A beta concentration in the integrative medicine treatment group: serum A beta concentration began to rise 1 week after modeling, increased significantly at 2~5 weeks, and then decreased gradually, which was still higher than that before modeling six months after treatment. Conclusion: Simply adding levothyroxine sodium and combination of traditional Chinese and Western medicine therapy could reduce hypothyroidism in aged rabbits’ serum amyloid beta protein concentrations; in this experiment, the effective time was three weeks after the treatment, and the time of obvious therapeutic effect was 4~6 months after treatment. But the combination of traditional Chinese and Western medicine therapy on serum amyloid beta protein concentration decreased from the model after the second month compared with simple western medicine treatment group.