中性粒细胞明胶酶相关脂质运载蛋白在肾损伤中的检测进展
Research Advances of Detection Methods for NGAL in Renal Injury
DOI: 10.12677/MD.2019.91001, PDF,   
作者: 孟萍*：广州市花都区人民医院肾病实验室，南方医科大学附属花都医院，广东 广州
关键词: 中性粒细胞明胶酶相关脂质运载蛋白；肾损伤；检测方法；NGAL； Renal Injury； Detection Methods
摘要: 中性粒细胞明胶酶相关脂质运载蛋白(NGAL)是一类小分子分泌型糖蛋白，其能迅速灵敏的反映肾脏的损伤程度及恢复过程，成为检测肾损伤的一个新的生物学标志物。因此建立NGAL的检测方法至关重要，目前有多种检测NGAL的方法：免疫印迹法、酶联免疫吸附法等，本文将对NGAL检测方法的原理及相关国内外研究进展的应用和局限进行总结归纳，为临床工作者检测及评估肾损伤程度提供一定的参考，同时也为今后开发新的检测方法提供理论参考和技术支持。
Abstract: Neutrophil gelatinase-associated lipocalin (NGAL) is a type of small molecules that secreted gly-coproteins. It can reflect the degree of renal injury and the process of recovery. It has become a new biological marker of renal injury. So it is very necessary to establish the detection methods of NGAL. There are many ways to detect NGAL, for example Western Blot, ELISA and so on. We will introduce the principle of methods that detecting NGAL and summarize the application and limitations of these detection methods. It will give some reference to evaluate the degree of renal injury and new methods to detect the renal injury.
文章引用：孟萍. 中性粒细胞明胶酶相关脂质运载蛋白在肾损伤中的检测进展[J]. 医学诊断, 2019, 9(1): 1-6. https://doi.org/10.12677/MD.2019.91001

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