从辣椒中提取分离高纯度辣椒碱的工艺研究
The Technology of Extracting and Separating Capsaicin from Capsicum
DOI: 10.12677/JOCR.2019.71003, PDF,    科研立项经费支持
作者: 张超, 牛亮峰*：许昌学院化学化工学院，河南 许昌；梁玮：许昌学院新材料与能源学院，河南 许昌；刘成, 陈振宇：许昌安成生物科技有限公司，河南 许昌
关键词: 辣椒碱；正交法；固态高纯；提取工艺；精制工艺；Capsaicin； Orthogonal Design； Solid High-Purity； Extraction Technology； Refining Process
摘要: 本文对辣椒中辣椒碱的提取和精制工艺进行了研究。通过对辣椒碱性质的分析，建立了前处理、提取、除杂、结晶四步生产工艺。并使用正交法对辣椒碱的提取工艺进行了详细研究，最佳的条件为以70%乙醇为萃取剂，料液质量比为1:4，在65℃下，搅拌提取2小时。获得的辣椒碱杂质少，纯度高，含量大于95%，优于美国药典USP40-NF35 (2017)对辣椒碱纯度的规定。本提取和精制工艺，方法简单、可行，提取效率高，为天然高纯辣椒碱的工业化生产提供了新途径。
Abstract: In this paper, the extraction technology and refining process of capsaicin from capsicum were studied. Based on the analysis of capsaicin, the four-step production processes were established, which includes pretreatment, extraction, purification and crystallization. The extraction process of capsaicin was researched by the orthogonal design, and the best conditions were using 70% ethanol as extraction agent, liquid mass ratio of 1:4, temperature 65˚C, and stirring for 2 hours. The obtained capsaicin has few impurities and high purity. The content of the target compounds is more than 95%, which is better than the regulations of the United States pharmacopoeia USP40-NF35 (2017) on the purity of capsaicin. The extraction and refining process is simple, feasible and efficient, which provides a new way for the industrial production of natural solid high purity capsaicin.
文章引用：张超, 牛亮峰, 梁玮, 刘成, 陈振宇. 从辣椒中提取分离高纯度辣椒碱的工艺研究[J]. 有机化学研究, 2019, 7(1): 18-25. https://doi.org/10.12677/JOCR.2019.71003

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