糖尿病视网膜病变危险因素及治疗进展
Risk Factors and Treatment Progress of Diabetic Retinopathy
DOI: 10.12677/HJO.2019.81005, PDF,   
作者: 黄凯瑞：蚌埠医学院第一附属医院，安徽 蚌埠
关键词: 糖尿病视网膜病变；危险因素；治疗方法；玻璃体切除术；Diabetic Retinopathy； Risk Factors； Therapy； Vitrectomy
摘要: 糖尿病视网膜病变(Diabetic Retinopathy, DR)是糖尿病危及视功能最严重的并发症，也是糖尿病患者致盲的首要原因及其发病原因。目前，糖尿病视网膜病变发病机制尚未完全明确，影响其发生发展因素也较为复杂，全身因素包括年龄、病程、血糖、血脂等。DR的治疗方式主要包括药物、激光、玻璃体切除手术、基因治疗等。本文就PDR的危险因素及治疗进展进行综述。
Abstract: Diabetic retinopathy (DR) is the most serious complication of diabetes that endangers visual func-tion, and is also the leading cause of blindness in diabetic patients. At present, the pathogenesis of diabetic retinopathy is not yet completely clear, and the factors affecting its occurrence and de-velopment are also complex. The systemic factors include age, course, blood sugar, and blood lipid. DR’s treatment methods mainly include drugs, lasers, vitrectomy and Chinese medicine. This article reviews the risk factors and treatment progress of DR.
文章引用：黄凯瑞. 糖尿病视网膜病变危险因素及治疗进展[J]. 眼科学, 2019, 8(1): 21-26. https://doi.org/10.12677/HJO.2019.81005

参考文献

[1] 高鑫. 糖尿病防治的现状与思考[J]. 泸州医学院学报, 2017, 40(1): 1-2.
[2] 刘子琪, 刘爱萍, 王培玉. 中国糖尿病患病率的流行病学调查研究状况[J]. 中华老年多器官疾病杂志, 2015(7): 547-550.
[3] Zhang, Y., Niu, M., Li, Y., et al. (2018) Prevalence and Risk Factors of Diabetic Retinopathy in Hospital Patients. Chinese Medical Journal, 98, 440-444.
[4] Abdelhakim, M.A.S.E., Macky, T.A., Mansour, K.A.G., et al. (2011) Bevacizumab (Avastin) as an Adjunct to Vitrectomy in the Management of Severe Proliferative Diabetic Retinopathy: A Prospective Case Series. Ophthalmic Research, 45, 23-30.
[Google Scholar] [CrossRef] [PubMed]
[5] Nittala, M.G., Keane, P.A., Zhang, K., et al. (2012) Risk Factors for Proliferative Di-abetic Retinopathy in a Latino American Population. Retina, 34, 1594-1599.
[Google Scholar] [CrossRef] 
[6] 崔颖, 郭海科, 韩云飞, 等. 2型糖尿病住院患者糖尿病视网膜病变患病率及危险因素分析[J]. 眼科新进展, 2012, 32(8): 736-739.
[7] 郭伟宾, 杨江萍, 侯娇娇, 等. 糖尿病视网膜病变的危险因素分析[J]. 解放军医药杂志, 2018(6).
[8] Czakó, C., Sándor, G., Ecsedy, M., et al. (2018) Decreased Retinal Capillary Density Is Associated with a Higher RISK of Diabetic Retinopathy in Patients with Diabetes. Retina.
[Google Scholar] [CrossRef] 
[9] Kaur, N. and Vanita, V. (2016) Association of Aldose Reductase Gene (AKR1B1) Polymorphism with Diabetic Retinopathy. Diabetes Research & Clinical Practice, 121, 41-48.
[Google Scholar] [CrossRef] [PubMed]
[10] Katakami, N., Kaneto, H., Takahara, M., Matsuoka, T.A., Imamura, K., Ishibashi, F., Kanda, T., Kawai, K., Osonoi, T., Matsuhisa, M., Kashiwagi, A., Kawamori, R., Shimomura, I. and Yamasaki, Y. (2011) Aldose Reductase C-106T Gene Polymorphism Is Associated with Diabetic Retinopathy in Japanese Patients with Type 2 Diabetes. Diabetes Research and Clinical Practice, 92, e57-e60.
[Google Scholar] [CrossRef] [PubMed]
[11] Ren, M., Zhao, L.L., Zhang, Y., Shi, Y., Mao, Y.M. and Qi, X.Y. (2014) Relationship between Polymorphisms of Aldose Reductase Gene and Type 2 Diabetic Retinopathy. Shandong Medical Journal, 54, 20-22
[12] Berry, D.C. and Noy, N. (2017) Retinol Binding Protein 4: Role in Diabetes and Cancer. Adipocytokines, Energy Balance, and Cancer.
[13] Kwanbunjan, K., Panprathip, P., Phosat, C., et al. (2018) Association of Retinol Binding Protein 4 and Transthyretin with Triglyceride Levels and Insulin Resistance in Rural Thais with High Type 2 Diabetes Risk. BMC Endocrine Disorders, 18, 26.
[Google Scholar] [CrossRef] [PubMed]
[14] Li, G., Esangbedo, I.C., Xu, L., et al. (2018) Childhood Retinol-Binding Protein 4 (RBP4) Levels Predicting the 10-Year Risk of Insulin Resistance and Metabolic Syndrome: The BCAMS Study. Cardiovascular Diabetology, 17, 69.
[Google Scholar] [CrossRef] [PubMed]
[15] Pandey, G.K., Balasubramanyam, J., Balakumar, M., et al. (2015) Altered Circulating Levels of Retinol Binding Protein 4 and Transthyretin in Relation to Insulin Resistance, Obesity, and Glucose Intolerance in Asian Indians. Endocrine Practice, 5, 7-13.
[16] Li, J.Y., Chen, X.X., Lu, X.H., et al. (2018) Elevated RBP4 Plasma Levels Were Associated with Diabetic Retinopathy in Type 2 Diabetes. Bioscience Reports, 38, BSR20181100.
[Google Scholar] [CrossRef] 
[17] Farjo, K.M., Farjo, R.A., Halsey, S., et al. (2012) Retinol-Binding Protein 4 Induces Inflammation in Human Endothelial Cells by an NADPH Oxidase- and Nuclear Factor Kappa B-Dependent and Retinol-Independent Mechanism. Molecular & Cellular Biology, 32, 5103-5115.
[Google Scholar] [CrossRef] 
[18] Kernt, M., Hadi, I., Pinter, F., et al. (2012) Assessment of Diabetic Retinopathy Using Nonmydriatic Ultra-Widefield Scanning Laser Ophthalmoscopy (OPTOMAP) Compared with ETDRS 7-Field Stereo Photography. Diabetes Care, 35, 2459.
[Google Scholar] [CrossRef] [PubMed]
[19] Ophthalmol, A. (1987) Photocoagulation for Diabetic Macular Edema. Early Treatment Diabetic Retinopathy Study Report Number 1. Early Treatment Diabetic Retinopathy Study Research Group. Archives of Ophthalmology, 94, 761-774.
[20] Jeong, S.H., Han, J.I., Cho, S.W., et al. (2016) Effect of Focal Laser Photocoagulation in Eyes with Mild to Moderate Non-Proliferative Diabetic Retinopathy. International Journal of Ophthalmology, 9, 1439.
[21] Zhao, Y. (2018) The Role of Anti-Vascular Endothelial Growth Factor (anti-VEGF) in the Management of Proliferative Diabetic Retinopathy. Drugs in Context, 7, Article ID: 212532.
[Google Scholar] [CrossRef] [PubMed]
[22] Holekamp, N.M., Bouck, N. and Volpert, O. (2002) Pigment Epithelium-Derived Factor Is Deficient in the Vitreous of Patients with Choroidal Neovascularization Due to Age-Related Macular Degeneration. American Journal of Ophthalmology, 134, 220-227.
[Google Scholar] [CrossRef] 
[23] Boyer, D.S., Yoon, Y.H., Jr., B.R., et al. (2014) Three-Year, Randomized, Sham-Controlled Trial of Dexamethasone Intravitreal Implant in Patients with Diabetic Macular Edema. Ophthalmology, 121, 1904-1914.
[Google Scholar] [CrossRef] [PubMed]
[24] Di, M.G., Reuter, S., Hillebrand, U., et al. (2009) The Soluble VEGF Re-ceptor sFlt1 Contributes to Endothelial Dysfunction in CKD. Journal of the American Society of Nephrology, 20, 2235-2245.
[Google Scholar] [CrossRef] 
[25] Tu, L., Wang, J.H., Barathi, V.A., et al. (2018) AAV-Mediated Gene Delivery of the Calreticulin Anti-Angiogenic Domain Inhibits Ocular Neovascularization. Angiogenesis, 21, 1-15.
[Google Scholar] [CrossRef] [PubMed]
[26] Brănişteanu, D.C., Bilha, A. and Moraru, A. (2016) Vitrectomy Surgery of Diabetic Retinopathy Complications. Romanian Journal of Ophthalmology, 60, 31-36.

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