一类描述肉芽肿生长的自由边界问题的数学分析
Analysis of a Free Boundary Problem Modeling the Granuloma Formation
DOI: 10.12677/PM.2019.92028, PDF,   
作者: 韩莹莹:华南理工大学数学学院,广东 广州
关键词: 肿瘤模型自由边界问题整体解Tumor Model Free Boundary Problem Global Solution
摘要: 本文研究描述一类肉芽肿瘤生长的自由边界问题,它由定义在移动区域上的相互耦合的抛物型和双曲型方程组构成。我们首先将自由边界问题转换成固定边界上的问题,然后利用抛物型方程的Lp理论、双曲方程的特征线理论和Banach不动点定理证明该问题局部解的存在唯一性,最后利用先验估计得到整体解的存在唯一性。
Abstract: In this paper we study a free boundary value problem modeling the growth of Leishmaniasis. It consists of coupled parabolic equations and hyperbolic equations with moving boundary. Firstly, we convert the free boundary problem into an equivalent problem defined on fixed domain. Then we use Lp theory of parabolic equations, characteristic theory of hyperbolic equations and Banach fixed point theorem to prove existence and uniqueness of a local solution. Finally we extend this local solution to be global by employing a priori estimate.
文章引用:韩莹莹. 一类描述肉芽肿生长的自由边界问题的数学分析[J]. 理论数学, 2019, 9(2): 217-229. https://doi.org/10.12677/PM.2019.92028

参考文献

[1] Siewe, N., Yakubu, A.-A., Satoskar, A.R. and Friedman, A. (2017) Granuloma Formation in Leishmaniasis: A Mathematical Model. Journal of Theoretical Biology, 412, 48-60.
[Google Scholar] [CrossRef] [PubMed]
[2] Friedman, A. and Reitech, F. (1999) Analysis of a Mathematical Model for the Growth of Tumors. Journal of Mathematical Biology, 38, 262-284.
[Google Scholar] [CrossRef] [PubMed]
[3] Cui, S. (2005) Analysis of a Free Boundary Problem Modeling Tumor Growth. Acta Mathematicae Applicatae Sinica, English Series, 21, 1071-1082.
[Google Scholar] [CrossRef
[4] 高帅帅, 卫雪梅, 冯兆永. 一个肿瘤化学治疗空间结构模型的定性分析[J]. 中山大学学报(自然科学版), 2012(51): 30-34.
[5] Wei, X. and Cui, S. (2007) Global Well-Posedness for a Drug Transport Model in Tumor Multicell Spheroids. Mathematical and Computer Modelling, 45, 553-562.
[Google Scholar] [CrossRef
[6] Wei, X. and Cui, S. (2007) Existence and Uniqueness of the Global Solutions for a Mathematical Model of the Use of Macrophages in Tumor Medicine. Nonlinear Analysis: Real World Applications, 8, 922-938.
[Google Scholar] [CrossRef
[7] 张久远, 冯兆永, 刘成霞, 卫雪梅. 关于肿瘤细胞破坏并入侵正常组织或细胞质基质的数学模型的分析[J]. 中山大学学报(自然科版), 2013(52): 48-54.
[8] Cui, S. and Wei, X. (2002) Global Existence for a Parabolic-Hyperbolic Free Boundaryproblem Modeling Tumor Growth. Acta Mathematicae Applicatae Sinica, English Series, 21, 469-486.