一锅法合成艾地苯醌
One-Pot Synthesis of Idebenone
DOI: 10.12677/JOCR.2019.71006, PDF,   
作者: 仇永富, 卢斌, 严燚宇, 汤倩, 张天丽, 何郁焙, 罗婉悦, 赵岩, 祁实, 田建华, 高振秋：盐城师范学院药学院，江苏 盐城；王金：盐城师范学院药学院，江苏 盐城；江苏省盐土生物资源研究重点实验室，江苏 盐城；卞勋光*：盐城师范学院，海洋与生物工程学院，江苏 盐城
关键词: 辅酶Q；艾地苯醌；偶联反应；Coenzyme Q； Idebenone； Coupling Reaction
摘要: 艾地苯醌是一种用于治疗帕金森病、阿尔采默氏病和脑动脉硬化症等多种疾病的辅酶Q类药物。本文以3,4,5-三甲氧基甲苯1为原料，一锅法简便高效合成艾地苯醌，总收率为60%，该法可应用于其他辅酶Q类药物的合成。
Abstract: Idebenone is a synthetic CoQ structural drug, which is used to treat Parkinson’s disease, Alz-heimer’s disease and cerebral arteriosclerosis. We reported herein one pot synthesis of Idebenone, with the overall yield of 60%. The reaction is operationally simple and could be used in the preparation of other biologically Coenzyme Q analogues.
文章引用：仇永富, 卢斌, 严燚宇, 汤倩, 张天丽, 何郁焙, 罗婉悦, 赵岩, 祁实, 田建华, 王金, 高振秋, 卞勋光. 一锅法合成艾地苯醌[J]. 有机化学研究, 2019, 7(1): 38-41. https://doi.org/10.12677/JOCR.2019.71006

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