Cajal间质细胞相关分子调控及临床疾病的研究进展
Research Progress of Molecular Regulation and Clinical Diseases of Interstitial Cells of Cajal
DOI: 10.12677/HJS.2019.82009, PDF,  被引量   
作者: 赵刚*, 陆启帆：上海市东方医院(同济大学附属东方医院)，上海
关键词: Cajal间质细胞；分子调控；临床疾病；胆囊功能；Interstitial Cells of Cajal； Molecular Regulation； Clinical Diseases； Gallbladder Function
摘要: Cajal间质细胞(Interstitial cells of Cajal, iccs)是一类主要存在于人消化系统并呈以网络状分布于胃、胆囊、膀胱、输卵管等部位的平滑肌层内间质细胞，属胃肠道慢波电位起搏细胞和信号传导细胞。通过目前的研究发现，存在有大量与调控iccs的数量、功能、表型分化相关的分子调控机制，包括氯离子通道蛋白(Anoctamin 1, Ano1)、酪氨酸激酶膜受体蛋白(c-kit)、重组干细胞因子(Stem cell factor, SCF)、脂多糖(Lipopolysaccharides, LPS)与肿瘤坏死因子-α (Tumor Necrosis Factor-α, TNF-α)等。同时也有大量报道指出，iccs与多种临床疾病的发生发展密不可分，包括胆囊结石、慢性假性肠梗阻、输卵管异位妊娠等。但目前iccs的分子调控机制与临床疾病之间的关系尚未十分明确。本文就iccs的起源、分类、相关分子调控机制及相关疾病等作一综述。
Abstract: Interstitial cells of Cajal (iccs) are such a kind of cells mainly found in the stomach, gallbladder, bladder and oviduct that work as the pacemaker and signal transduction cells. Through current research, it is found that there are a large number of molecular regulatory mechanisms related to the regulation of the number, function and phenotypic differentiation of iccs, including anoctamin 1 (Ano1), C-kit, stem cell factor (SCF), lipopolysaccharide (LPS) and tumor necrosis factor-α (TNF-α). At the same time, there are a large number of reports that iccs are inseparable from the development of various clinical diseases, including gallstones, chronic pseudo-intestinal obstruction, and tubal ectopic pregnancy. However, the relationship between the molecular regulation mechanism of iccs and clinical diseases is not yet clear. This article will review the origin, classification, related molecular regulation mechanisms and related diseases of iccs.
文章引用：赵刚, 陆启帆. Cajal间质细胞相关分子调控及临床疾病的研究进展[J]. 外科, 2019, 8(2): 51-58. https://doi.org/10.12677/HJS.2019.82009

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