镇肝熄风汤治疗糖尿病并脑梗死患者急性期临床疗效、神经功能及预后分析

Clinical Effect, Neurological Function and Prognosis of Patients with Diabetes Mellitus Complicated with Cerebral Infarction Treated with Zhengan Xifeng Decoction

摘要: 目的：分析糖尿病并脑梗死患者急性期采用镇肝熄风汤治疗的疗效及对神经功能与预后的影响。方法：选择我院2016年1月~2018年6月诊治的76例急性期糖尿病并脑梗死患者，随机分成研究组(38例)和对照组(38例)。对照组接受常规西药治疗，研究组予以常规西药联合镇肝熄风汤治疗，比较两组临床效果。结果：研究组治疗后2 hPG (8.52 ± 1.26) mmol/L、FBG (6.23 ± 0.54) mmol/L、TG (1.06 ± 0.35) mg/L、HCY (9.21 ± 3.02) μmol/L，优于对照组(P < 0.05)；研究组ADL (58.46 ± 10.23)分、NIHSS (8.92 ± 2.83)分、MFMA (55.08 ± 4.43)分，优于对照组(P < 0.05)；研究组血小板聚集率(56.98 ± 6.87)%、全血高切(4.29 ± 1.04) mPa∙s、全血低切(7.20 ± 1.36) mPa∙s、血浆粘度(1.47 ± 0.16) mPa∙s，优于对照组(P < 0.05)；研究组CRP (9.65 ± 3.14) mg/L、TNF-α (1.02 ± 0.25) ng/L、IL-1 (0.63 ± 0.12) ng/L、IL-6 (95.36 ± 30.34) μg/L，优于对照组(P < 0.05)。结论：镇肝熄风汤对糖尿病并脑梗死急性期疗效确切，可改善血糖血脂，提升日常生活能力与神经功能，减轻炎症反应，改善血液流变学指标。

Abstract: Objective: To study the effect of the treatment and the effect on the neurological function and the prognosis in the acute phase of the patients with diabetes and cerebral infarction. Methods: 76 pa-tients with acute and cerebral infarction from January to June of 2016 were randomly divided into the study group (38 cases) and the control group (38 cases). The control group received the routine western medicine treatment, and the study group received the conventional western medicine combined with the treatment of the liver-calming and wind-out decoction to compare the two groups of clinical effects. Results: The study group after treatment was with 2 hPG (8.52~1.26) mmol/L, FBG (6.23~0.54) mmol/L. L, TG (1.06 ± 0.35) mg/L, HCY (9.21 ± 3.02) μmol/L, which were better than those of the control group (P < 0.05). ADL (58.46 ± 10.23), NIHSS (8.92 ± 2.83), MFMA (55.08 ± 4.43) in the study group were better than those in the control group (P < 0.05). In the study group, platelet aggregation rate was (56.98 ± 6.87)%, whole blood high shear rate was (4.29 ± 1.04) mPa∙s, whole blood low shear rate was (7.20 ± 1.36) mPa∙s, plasma viscosity was (1.47 ± 0.16) mPa∙s, which were better than those of the control group (P < 0.05). The CRP of the study group was (9.65 ± 3.14) mg/L, TNF-α (1.02 ± 0.25) ng/L, IL-1 (0.63 ± 0.12) ng/L, IL-6 (95.36 ± 30.34) μg/L, which were better than those of the control group (P < 0.05). Conclusion: Zhengan Xifeng decoction is effective in the treatment of diabetes mellitus complicated with cerebral infarction in the acute phase. It can improve blood sugar and blood lipid, enhance the ability of daily living and nerve function, lighten the inflammatory reaction and improve the hemorheological indexes.