Bavencio (Avelumab)新药的治疗作用研究
Study on the Therapeutic Effect of New Drug Bavencio (Avelumab)
DOI: 10.12677/PI.2019.83007, PDF,   
作者: 邱天琦*, 苏书杰:辽宁大学药学院,辽宁 沈阳
关键词: Avelumab默克尔细胞癌Pd-L1JAVELIN200Avelumab MCC Pd-L1 JAVELIN200
摘要: 2017年,美国食品药品监督管理局(FDA)加速批准了新药Bavencio,主要成分Avelumab。该药对转移性默克尔细胞癌(mMCC)具有持续缓解作用,它在美国已被加速批准用于治疗成人和12岁儿童的默克尔细胞癌(MCC)。在欧洲,治疗转移性尿路上皮癌生物制剂许可证申请也在接受FDA的优先审查,对于不同癌症治疗正处于发展阶段。本篇文章将讲述该药对于默克尔细胞癌以及转移性尿路上皮癌等几个方面的治疗作用,从药效学,药物动力学,临床试验及副反应等方面进行总结并对Avelumab类新药进行进一步发展进行探讨。
Abstract: In 2017, the United States FDA approved a number of new drugs, including Bavencio, a major ingredient in Avelum ab. Today we will mainly introduce the development and approval of these new drugs. Avelum abababa Bavencio is an intravenous programmed cell death ligand-1-blocking human antibody which is used in the treatment of various tumors. It has accelerated approval in the United States for the treatment of Merkel’s cell carcinoma in adults and 12-year-old. Treatment of urothelial epithelium in the EU with Avelumab Cancer biologics license applications are being re-viewed by FDA as a priority for different cancer treatments. This article will describe the therapeutic effects of the drug on Merkel’s cell carcinoma and metastatic urothelial carcinoma, summarize the pharmacodynamics, pharmacokinetic and side effects of the drug and discuss the further development of new Avelumab drugs.
文章引用:邱天琦, 苏书杰. Bavencio (Avelumab)新药的治疗作用研究[J]. 药物资讯, 2019, 8(3): 56-61. https://doi.org/10.12677/PI.2019.83007

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