探究高尿酸血症与脑梗死的临床预后相关性分析

Exploring the Correlation between the Clinical Prognosis of Hyperuricemia and Cerebral Infarction

摘要: 目的：探究高尿酸血症与脑梗死的临床预后相关性分析。方法：选取延安大学附属医院东关分院神经内科2018年1月至2019年1月被确诊为脑梗死合并高尿酸血症的患者206例，该研究经延安大学附属医院伦理委员会批准，所有患者或其家属均签署知情同意书，入院24 h内测量血清尿酸值，并采用美国国立卫生院脑卒中量表(NIHSS)和改良Rankin量表(mRS)评估患者入院时神经功能缺陷，出院后第90天再次测量血清尿酸值、NIHSS和mRS评估卒中后远期神经功能恢复情况。结果：入院时男女性尿酸值、NIHSS评分和mRS评分分别高于第90天时男女性尿酸值、NIHSS评分和mRS评分，P < 0.05，差异有统计学意义。结论：高尿酸对脑血管疾病有较大不利因素，高尿酸血症对卒中后神经功能恢复影响较大。

Abstract: Objective: To investigate the correlation between hyperuricemia and clinical prognosis of cerebral infarction. Methods: A total of 206 patients with cerebral infarction complicated with hyperurice-mia were enrolled in the Department of Neurology, Dongguan Hospital of Yan’an Affiliated Hospital from January 2018 to January 2019. The study was approved by the ethics committee of the hospital affiliated to Yan’an University; all patients or their families signed the informed consent. The serum uric acid value was measured within 24 hours after admission and was used by the Na-tional Institutes of Health. The Stroke Scale (NIHSS) and the Modified Rankin Scale (mRS) were used to assess neurological deficits at admission. The serum uric acid, NIHSS, and mRS scales were measured again on the 90th day after discharge to assess long-term neurological recovery after stroke. Results: At admission male and female uric acid levels, NIHSS scores and mRS scores were significantly higher than those after the 90th day uric acid levels, NIHSS scores and mRS scores, P < 0.05, and the difference was statistically significant. Conclusion: High uric acid has great adverse effects on cerebral vascular disease, and hyperuricemia has a great effect on the recovery of neu-rological function after stroke.