内蒙古地区过敏原检测结果与特禀体质相关性的初步探讨

A Preliminary Study on the Correlation between the Results of Allergen Detection and the Specific Constitution in Inner Mongolia

摘要: 目的：探讨内蒙古地区过敏原流行特征及过敏原与特禀体质的相关性，为临床诊断、治疗及预防提供参考依据。方法：采用临床流行病调查统计的方法收集了内蒙古医科大学附属医院2016年6月至2017年5月内蒙古地区不同年龄过敏性疾病患者20种过敏原特异性IgE抗体检测结果，并对过敏原阳性患者进行特禀体质的判断。结果：4902例患者中过敏原阳性率为48.3%，其中女性过敏原阳性率较高(P < 0.01)；不同年龄阶段同一过敏原阳性率表现为D1、H1、E1、E5、I6、W14、F91、F202、WxCHN、Tx-CHN均在青年时期阳性率最高(P < 0.05)，F1、F2则在幼儿时期阳性率最高(P < 0.05)；不同月份同一过敏原阳性率也不同，表现为H1、T70、E1、E5、W14、F1、F2、F27、F91、F202、WxCHN、Tx-CHN均在8月份阳性率最高(P < 0.05)，具有统计学意义，D1则在11月份阳性率最高(P < 0.05)，F23 (P < 0.05)则在10月份阳性率最高；，具有统计学意义，同一种过敏原不同季节阳性率也不同，表现为H1、T70、E1、E5、W14、F1、F2、F91、F202、WxCHN均在夏季阳性率最高(P < 0.05)，D1、F27、F23则在秋季阳性率最高(P < 0.05)，F210、Tx-CHN则在冬季阳性率最高(P < 0.05)，而过敏原阳性患者中有74.7%为特禀体质。结论：20种过敏原特异性IgE抗体在不同年龄段、在不同月份、在不同季节的阳性率均有不同高低表现差异，同时过敏性疾病患者与特禀体质可能存在一定的相关性，但需要进一步研究，望其可以为内蒙古地区治疗过敏性疾病提供部分参考依据。

Abstract: Objective: To investigate the epidemiological characteristics of allergens in allergic diseases in Inner Mongolia and their correlation with specific constitution, so as to provide reference for clinical diagnosis, treatment and prevention. Methods: 20 allergen specific IgE antibodies were collected from the Affiliated Hospital of Inner Mongolia Medical University from June 2016 to May 2017 in Inner Mongolia Medical University Affiliated Hospital, and the specific body quality of the patients with allergens was judged. Result: Among all these 4902 patients, anaphylactogen’s positive rate is 48.3% and it is higher when comes to female (P < 0.01), and it varies from age to age even in the same type. D1, H1, E1, E5, I6, W14, F91, F202, WxCHN, Tx-CHN all get their highest positive rate during the youth period, and F1, F2 peak their positive rate in the initial stage and have a average P < 0.05, which have statistical significance. The same anaphylactogen in different months of a year also has a difference on its positive rate: H1, T70, E1, E5, W14, F1, F2, F27, F91, F202, WxCHN, Tx-CHN which become highest of their positive rate in August, while D1’s positive rate becomes highest in November, and F23 in October (P < 0.05), which also have statistical significance. It happens that there is a similar phenomenon; the same anaphylactogen differs from season to season in a year; H1, T70, E1, E5, W14, F1, F2, F91, F202, WxCHN all climb to the top of their positive rate (P < 0.05), D1, F27, F23 in autumn (P < 0.05) and F210, Tx-CHN in winter (P < 0.05), and 74.7% of the patients with allergen are special constitution. Conclusions: The positive rate 20 kinds of allergen specific IgE antibody in different age groups, in different months, in different seasons have different performance difference on any account; at the same time, there may be some correlation between people with allergic diseases and specific constitution; but further study is needed; it can be for treatment of allergic disease in Inner Mongolia to provide some reference.