纳米粒眼用给药系统的研究进展
Research Progress of Nanoparticle Ophthalmic Drug Delivery System
摘要: 由于眼部给药屏障和传统给药技术的缺陷，越来越多治疗眼病的眼科给药技术被开发出来。但药物在眼睛表面停留时间短暂、给药剂量高和给药频繁、生物利用度低，仍是研究工作者面临的巨大挑战。纳米粒作为药物载体在提高药物对眼部屏障的穿透性、药用靶向性和生物利用度方面有极大的提高，开发利用纳米制剂将会提供更加有益的治疗效果。本综述主要就纳米粒制剂最新进展中的DNA纳米粒和纳米粒水凝胶隐形眼镜进行归纳分析，以期获得活性更强的靶向治疗的眼用制剂药物。
Abstract: More and more ophthalmic drug delivery technologies have been developed to treat eye diseases due to the defects of ocular drug delivery barriers and traditional drug delivery technologies. How-ever, the short duration of drug stay on the surface of eyes, high dose, frequent drug administration and low bioavailability are still great challenges facing researchers. Nanoparticles, as drug carriers, have greatly improved the penetration, drug targeting and bioavailability of drugs to the eye barrier, and the development and utilization of nano-preparations will provide more beneficial therapeutic effects. In this review, DNA nanoparticles and nanoparticle hydrogel contact lenses in the latest development of nanoparticle preparation were summarized and analyzed in order to obtain more active and targeted therapeutic ophthalmic preparations.
文章引用：张闯, 于焱杰, 赵咨鉴, 刘宇. 纳米粒眼用给药系统的研究进展[J]. 药物资讯, 2019, 8(3): 73-78. https://doi.org/10.12677/PI.2019.83009

参考文献

[1] Huang, D., Chen, Y.-S. and Rupenthal, I.D. (2018) Overcoming Ocular Drug Delivery Barriers through the Use of Physical Forces. Advanced Drug Delivery Reviews, 126, 96-112. [Google Scholar] [CrossRef] [PubMed]
[2] 杨龙, 陈凌云, 魏刚. 眼用脂质纳米制剂的研究进展[J]. 中国医药工业杂志, 2016, 47(12): 1592-1599.
[3] Hsu, K.-H., Gause, S. and Chauhan, A. (2014) Review of Ophthalmic Drug Delivery by Contact Lenses. Journal of Drug De-livery Science and Technology, 24, 123-135. [Google Scholar] [CrossRef] 
[4] Baudouin, C., Labbé, A., Liang, H. and Pauly, A. (2010) Françoise Brignole-Baudouin, Preservatives in Eyedrops: The Good, the Bad and the Ugly. Progress in Retinal and Eye Research, 29, 312-334. [Google Scholar] [CrossRef] [PubMed]
[5] 陈智, 冯杨, 朱荣刚. 眼用药物制剂的研究进展[J]. 食品与药品, 2012, 14(5): 213-216.
[6] Chang, M., Yang, C.-S. and Huang, D.-M. (2011) Aptamer-Conjugated DNA Icosahedral Nanoparticles as a Carrier of Doxorubicin for Cancer Therapy. ACS Nano, 5, 6156-6163. [Google Scholar] [CrossRef] [PubMed]
[7] de Vries, J.W., Schnichels, S., Hurst, J., Strudel, L., Gruszka, A., Kwak, M., Bartz-Schmidt, K.-U., Spitzer, M.S. and Herrmann, A. (2018) DNA Nanoparticles for Ophthalmic Drug Delivery. Biomaterials, 157, 98-106. [Google Scholar] [CrossRef] [PubMed]
[8] Nagarwal, R.C., Singh, P.N., Kant, S., Maiti, P. and Pandit, J.K. (2011) Chitosan Nanoparticles of 5-Fluorouracil for Ophthalmic Delivery: Characterization, In-Vitro and In-Vivo Study. Chemical and Pharmaceutical Bulletin, 59, 272-278. [Google Scholar] [CrossRef] [PubMed]
[9] Janagam, D.R., Wu, L. and Lowe, T.L. (2017) Nanoparticles for Drug Delivery to the Anterior Segment of the Eye. Advanced Drug De-livery Reviews, 122, 31-64. [Google Scholar] [CrossRef] [PubMed]
[10] Kim, Y.C., Chiang, B., Wu, X. and Prausnitz, M.R. (2014) Ocular Delivery of Macromolecules. Journal of Controlled Release, 190, 172-181. [Google Scholar] [CrossRef] [PubMed]
[11] Chen, H., Jin, Y., Sun, L., Li, X., Nan, K., Liu, H., Zheng, Q. and Wang, B. (2018) Recent Developments in Ophthalmic Drug Delivery Systems for Therapy of Both Anterior and Posterior Segment Diseases. Colloid and Interface Science Communications, 24, 54-61. [Google Scholar] [CrossRef] 
[12] Gaudana, R., Ananthula, H.K., Parenky, A. and Mitra, A.K. (2010) Ocular Drug Delivery. The AAPS Journal, 12, 348-360. [Google Scholar] [CrossRef] [PubMed]
[13] Englert, C., Brendel, J.C., Majdanski, T.C., Yildirim, T., Schubert, S., Gottschaldt, M., Windhab, N. and Schubert, U.S. (2018) Pharmapolymers in the 21st Century: Synthetic Polymers in Drug Delivery Applications. Progress in Polymer Science, 87, 107-164. [Google Scholar] [CrossRef] 
[14] Tran, V.-T., Benoît, J.-P. and Venier-Julienne, M.-C. (2011) Why and How to Prepare Biodegradable, Monodispersed, Polymeric Microparticles in the Field of Pharmacy? International Journal of Pharmaceutics, 407, 1-11. [Google Scholar] [CrossRef] [PubMed]
[15] Bertrand, N., Wu, J., Xu, X., Kamaly, N. and Farokhzad, O.C. (2014) Cancer Nanotechnology: The Impact of Passive and Active Targeting in the Era of Modern Cancer Biology. Ad-vanced Drug Delivery Reviews, 66, 2-25. [Google Scholar] [CrossRef] [PubMed]
[16] Zhou, H.Y., Hao, J.L., Wang, S., Zheng, Y. and Zhang, W.S. (2013) Nanoparticles in the Ocular Drug Delivery. International Journal of Ophthalmology, 6, 390-396.
[17] Bu, H.-Z., Gukasyan, H.J., Goulet, L., Lou, X.-J., Xiang, C. and Koudriakova, T. (2007) Ocular Disposition, Pharmacokinetics, Ef-ficacy and Safety of Nanoparticle-Formulated Ophthalmic Drugs. Current Drug Metabolism, 8, 91-107. [Google Scholar] [CrossRef] [PubMed]
[18] Mahor, A., Prajapati, S.K., Verma, A., Gupta, R., Iyer, A.K. and Kesharwani, P. (2016) Moxifloxacin Loaded Gelatin Nanoparticles for Ocular Delivery: Formulation and In-Vitro, In-Vivo Evaluation. Journal of Colloid and Interface Science, 483, 132-138. [Google Scholar] [CrossRef] [PubMed]
[19] Bochot, A. and Fattal, E. (2012) Liposomes for Intravitreal Drug Delivery: A State of the Art. Journal of Controlled Release, 161, 628-634. [Google Scholar] [CrossRef] [PubMed]
[20] Zhang, K., Hao, L., Hurst, S.J. and Mirkin, C.A. (2012) Anti-body-Linked Spherical Nucleic Acids for Cellular Targeting. Journal of the American Chemical Society, 134, 16488-16491. [Google Scholar] [CrossRef] [PubMed]
[21] Anaya, M., Kwak, M., Musser, A.J., Müllen, K. and Herrmann, A. (2010) Tunable Hydrophobicity in DNA Micelles: Design, Synthesis, and Characterization of a New Fam-ily of DNA Amphiphiles. Chemistry: A European Journal, 16, 12852-12859. [Google Scholar] [CrossRef] [PubMed]
[22] Zhu, Q., Wei, Y., Li, C. and Mao, S. (2018) Inner Layer-Embedded Contact Lenses for Ion-Triggered Controlled Drug Delivery. Materials Science and Engineering: C, 93, 36-48. [Google Scholar] [CrossRef] [PubMed]
[23] White, C.J., Tieppo, A. and Byrne, M.E. (2011) Controlled Drug Release from Contact Lenses: A Comprehensive Review from 1965-Present. Journal of Drug Delivery Science and Technology, 21, 369-384. [Google Scholar] [CrossRef] 
[24] Tummala, G.K., Joffre, T., Rojas, R., Perssonb, C. and Mih-ranyan, A. (2017) Strain-Induced Stiffening of Nanocellulose-Reinforced Poly(vinyl alcohol) Hydrogels Mimicking Collagenous Soft Tissues. Soft Matter, 13, 3936-3945. [Google Scholar] [CrossRef] 
[25] Åhlén, M., Tummala, G.K. and Mihranyan, A. (2018) Nanoparti-cle-Loaded Hydrogels as a Pathway for Enzyme-Triggered Drug Release in Ophthalmic Applications. International Journal of Pharmaceutics, 536, 73-81. [Google Scholar] [CrossRef] [PubMed]
[26] Li, X., Cui, Y., Lloyd, A.W., Mikhalovsky, S.V., Sandeman, S.R., Howel, C.A. and Liao, L. (2008) Polymeric Hydrogels for Novel Contact Lens-Based Ophthalmic Drug Delivery Systems: A Review. Contact Lens and Anterior Eye, 31, 1367-1484. [Google Scholar] [CrossRef] [PubMed]
[27] Tuwahatu, C.A., Yeung, C.C., Lam, Y.W. and Roy, V.A.L. (2018) The Molecularly Imprinted Polymer Essentials: Curation of Anticancer, Ophthalmic, and Projected Gene Therapy Drug Delivery Systems. Journal of Controlled Release, 287, 24-34. [Google Scholar] [CrossRef] [PubMed]
[28] Imperiale, J.C., Acosta, G.B. and Sosnik, A. (2018) Poly-mer-Based Carriers for Ophthalmic Drug Delivery. Journal of Controlled Release, 285, 106-141. [Google Scholar] [CrossRef] [PubMed]
[29] Kim, H.-J., Zhang, K., Moore, L. and Ho, D. (2014) Diamond Nanogel-Embedded Contact Lenses Mediate Lysozyme-Dependent Therapeutic Release. ACS Nano, 8, 2998-3005. [Google Scholar] [CrossRef] [PubMed]