双醋瑞因联合甲氨蝶呤治疗类风湿性关节炎患者的效果观察

Observation of Effect of Diacine Combined with Methotrexate on Patients with Rheumatoid Arthritis

摘要: 目的：探讨双醋瑞因联合甲氨蝶呤治疗类风湿性关节炎患者的临床效果。方法：随机选择本院收治的类风湿性关节炎患者104例进行研究，均于2015年8月至2017年8月期间收治，依据治疗方案分组各52例，对照组为甲氨蝶呤治疗，观察组则为双醋瑞因联合甲氨蝶呤治疗，观察两组症状改善情况、血清炎症因子变化及不良反应率等。结果：治疗后两组症状改善各指标均明显改善，其中与对照组比较，观察组改善效果更好，P < 0.05；治疗后，观察组炎症因子水平明显降低，且降低程度显著优于对照组，P < 0.05；观察组治疗有效率为96.15%，与对照组82.69%比较差异显著，优势明显，P < 0.05。观察组不良反应率为7.69%，与对照组11.53%比较无明显差异，P > 0.05。结论：在类风湿性关节炎治疗中选择双醋瑞因联合甲氨蝶呤治疗方案可有效促使患者症状改善，利于控制血清炎症因子得以降低，而且治疗安全性较高，不会增加不良反应的发生，临床治疗价值较高。

Abstract: Objective: To investigate the clinical effect of diacetate combined with methotrexate in the treatment of rheumatoid arthritis. Methods: One hundred and four patients with rheumatoid ar-thritis were randomly selected from August 2015 to August 2017. 52 patients were divided into two groups according to the treatment scheme, and the control group was treated with metho-trexate. The treatment group was treated with diacetate and methotrexate. The improvement of symptoms, the changes of serum inflammatory factors and the rate of adverse reactions were observed. Results: After treatment, the symptoms of the two groups improved obviously, and the effect of the observation group was better than that of the control group (P < 0.05). After treatment, the level of inflammatory factors in the observation group was significantly lower than that in the control group (P < 0.05), and the effective rate of treatment in the observation group was 96.15%, which was significantly different from that in the control group (82.69%) (P < 0.05). The adverse reaction rate of the observation group was 7.69%, and there was no significant difference between the observation group and the control group (11.53%, P > 0.05). Conclusion: The combination of diacetate and methotrexate in the treatment of rheumatoid arthritis can effectively improve the symptoms of the patients, help to control the decrease of serum inflammatory factors, and the safety of the treatment will not increase adverse reactions. Clinical treatment value is higher.