肠道菌群与阿尔茨海默病的相关性研究进展
Research Progress on the Relationship between Intestinal Flora and Alzheimer’s Disease
DOI: 10.12677/ACM.2019.95107, PDF,  被引量    科研立项经费支持
作者: 魏佳慧, 郭 鹏：山西医科大学第二临床医学院，山西 太原；赵 峰, 董靖玮, 王晓峰：山西医科大学麻醉学院，山西 太原
关键词: 肠道菌群；阿尔茨海默病；脑–肠轴；认知功能障碍；Intestinal Flora； Alzheimer’s Disease； Brain-Gut Axis； Cognitive Dysfunction
摘要: 阿尔茨海默病(AD)是一种中枢神经退行性病变，目前已成为全球面临的重大健康和社会经济问题之一，至今仍未找到有效的防治方法。研究显示，肠道菌群可以通过脑–肠轴影响β淀粉样蛋白(Aβ)的沉积、tau蛋白的过度磷酸化和神经炎症等AD典型病理特征。近几年兴起的微生物制剂和粪菌移植方法能够阻止AD相关的认知功能障碍的发生发展。因此，本文就肠道菌群与AD的相关性研究展开综述，旨在寻找防治AD的新策略。
Abstract: Alzheimer’s disease (AD) is a central nervous system degenerative disease that has become one of the major health and socioeconomic problems facing the world. No effective prevention and treatment methods have been found so far. Studies have shown that the intestinal flora can affect the typical pathological features of AD such as deposition of amyloid β (Aβ), hyperphosphorylation of tau, and neuroinflammation through the brain-gut axis. Microbial preparations and fecal trans-plantation methods that have emerged in recent years can prevent the development of AD-related cognitive dysfunction. Therefore, this article reviews the correlation between intestinal flora and AD, aiming to find new strategies for prevention and treatment of AD.
文章引用：魏佳慧, 赵峰, 董靖玮, 王晓峰, 郭鹏. 肠道菌群与阿尔茨海默病的相关性研究进展[J]. 临床医学进展, 2019, 9(5): 703-710. https://doi.org/10.12677/ACM.2019.95107

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