2型糖尿病大血管病变患者颈动脉内中膜厚度与血清CRP及Cys-C水平的相关性研究

The Relevant Research between Carotid Intima-Media Thickness in Patients with Type 2 Diabetic Macroangiopathy, Serum CRP, and Level of Cys-C

摘要: 目的：探讨2型糖尿病(T2DM)大血管病变患者颈动脉内中膜厚度(CIMT)与血清C反应蛋白(CRP)、胱抑素C (Cys-C)水平的相关性。方法：选择本院2016年3月~2018年3月收治的T2DM大血管病变患者52例、单纯T2DM患者60例及同期体检正常人员50例，分别纳入病变组、T2DM组、对照组。测定比较各组血糖、血脂、CIMT、血清CRP、Cys-C水平，CIMT与血清CRP、Cys-C之间行Pearson相关性分析，大血管病变的危险因素行Logistic回归分析。结果：病变组空腹血糖(FPG)、餐后2小时血糖(2 hPG)、糖化血红蛋白(HbAlc)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、CIMT、CRP及Cys-C水平水平均显著大于T2DM组、对照组，且T2DM组均显著大于对照组，差异有统计学意义(P < 0.05)；CIMT与血清CRP、Cys-C水平均正相关(P < 0.01)；Logistic多元逐步回归分析T2DM患者大血管病变的独立危险因素包括高HbAlc、LDL-C、CRP及Cys-C水平(P < 0.05)。结论：T2DM大血管病变患者CIMT与血清CRP、Cys-C正相关。

Abstract: Objective: To investigate the relationship between carotid intima-media thickness (CIMT) in pa-tients with type 2 diabetes mellitus (T2DM), serum C-reactive protein (CRP) and level of cystatin C (Cys-C). Methods: 52 patients with T2DM macroangiopathy, 60 patients with T2DM alone, 50 pa-tients with normal physical examination from March 2016 to March 2018 were selected; they were divided into the lesion group, T2DM group and control group respectively. Blood glucose, blood lipids, CIMT, serum CRP, the level of Cys-C, the correlation analysis between CIMT and serum CRP and Cys-C and logistic regression analysis for the risk factors of macrovascular disease were measured. Results: Fasting blood glucose (FPG), 2 hours postprandial blood glucose (2 hPG), gly-cosylated hemoglobin (HbAlc), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), CIMT, CRP and the level of Cys-C in the lesion group were significantly greater than those in the T2DM group and the control group (P < 0.05); CIMT was positively correlated with serum CRP and Cys-C levels (P < 0.01); independent risk factors for macrovascular disease in patients with T2DM included high HbAlc, LDL-C, CRP, and level of Cys-C by logistic multiple stepwise regression analysis (P < 0.05). Conclusion: CIMT in patients with T2DM macrovascular disease is positively correlated with serum CRP and Cys-C.