连续性血液净化治疗脓毒血症及并发MODS后临床疗效观察

Clinical Observation of Continuous Blood Purification in the Treatment of Sepsis and Complicated with MODS

摘要: 目的：探讨连续性血液净化治疗脓毒血症及并发多器官功能不全综合征(MODS)后临床疗效。方法：2011年6月至2016年6月期间，选择在本院接受治疗的脓毒血症患者例进行研究，其中将未并发多器官功能不全综合征患者82例作为对照组，将并发多器官功能不全综合征患者102例作为观察组，均行连续性血液净化治疗，观察治疗效果。结果：治疗前两组患者平均动脉压、呼吸频率、心率及血氧饱和度比较无明显差异，P > 0.05；治疗后，对照组各指标明显改善，且改善程度显著优于观察组，P < 0.05。治疗前两组患者ALT、Scr、TNF-α、IL-1、IL-8等指标比较无明显差异，P > 0.05；治疗后观察组患者各项实验室指标均改善，但效果较对照组差，组间比较差异明显，P < 0.05。结论：采用连续性血液净化治疗脓毒血症及并发多器官功能不全综合征患者可有效稳定身体状态和炎性指标，但仍需注意应尽早结合其病情实施个性化综合治疗，预防脓毒血症并发多器官功能不全综合征，尽早控制病情，改善健康状态。

Abstract: Objective: To investigate the clinical effect of continuous blood purification in the treatment of sepsis and multiple organ dysfunction syndrome (MODS). Methods: From June 2011 to June 2016, 82 patients with sepsis who received treatment in our hospital were selected as the control group. 102 patients with multiple organ dysfunction syndrome were treated with continuous blood puri-fication. Results: There was no significant difference in mean arterial pressure, respiratory rate, heart rate and oxygen saturation between the two groups before treatment (P > 0). After treatment, the indexes of the control group were obviously improved, and the degree of improvement was significantly better than that of the observation group (P < 0.05). Before treatment, there was no significant difference between the two groups (P > 0.05), but all the laboratory indexes in the observation group were improved, but the effect was worse than that in the control group, and the difference between the two groups was significant (P < 0.05). Conclusion: Continuous blood puri-fication for patients with sepsis and complicated multiple organ dysfunction syndrome can effec-tively stabilize the body state and inflammatory index, but it is still necessary to pay attention to the combination of the disease as soon as possible to implement personalized comprehensive treatment to prevent sepsis complicated by multiple organ dysfunction syndrome, early control the disease and improve health.