龙血素B衍生物的合成及生物活性研究进展
Advances in Synthesis and Biological Activity of Loureirin B Derivatives
DOI: 10.12677/JOCR.2019.72008, PDF,    国家自然科学基金支持
作者: 林俊洁, 潘小霞*, 刘花, 李正英, 黄超*：云南民族大学化学与环境学院，云南 昆明
关键词: 龙血素B；二氢查尔酮；羟醛缩合；生物活性；Loureirin B； Dihydrochalcone； Aldol Condensation； Biological Activity
摘要: 龙血素B是传统名贵中药材龙血竭的主要成分之一，也是龙血竭制剂国家药品标准中规定的指标性成分的标准对照物质。基于龙血素B的应用前景，本文综述了龙血素B衍生物的合成方法，利用简单的芳香醛和芳香酮通过羟醛缩合得到结构多样性的查尔酮类化合物，再将其还原得到二氢查尔酮。同时还整理了龙血素B具有镇痛、活血化瘀、消肿止痛、敛疮生肌等生物活性。希望通过本文能为后续龙血素B的研究提供参考。
Abstract: Loureirin B is one of the main ingredients of Dragon’s Blood, which is one of the most valuable traditional Chinese medicines. It is also the standard reference substance of the index ingredients stipulated in the national drug standard of Dragon’s Blood preparation. Based on the application prospects of Loureirin B, the synthesis methods of Loureirin B derivatives were reviewed. Chalcones with various structures were synthesized by aldol condensation of simple aromatic aldehydes and ketones, and then dihydrochalcones were reduced. At the same time, the biological activities of Loureirin B, such as analgesia, activating blood circulation and removing blood stasis, detumescence, pain relief, sore and muscle regeneration, were also sorted out. It is hoped that this paper can provide reference for the follow-up study of Loureirin B.
文章引用：林俊洁, 潘小霞, 刘花, 李正英, 黄超. 龙血素B衍生物的合成及生物活性研究进展[J]. 有机化学研究, 2019, 7(2): 54-62. https://doi.org/10.12677/JOCR.2019.72008

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