二甲双胍对胃癌抗肿瘤作用的研究进展
Research Progress on Anti-Tumor Effect of Metformin in Gastric Cancer
DOI: 10.12677/ACM.2019.97128, PDF,   
作者: 贺礼琴, 张双双, 冯义朝：延安大学附属医院，陕西 延安
关键词: 二甲双胍；胃癌；抗肿瘤作用；Metformin； Gastric Cancer； Anti-Tumor Effect
摘要: 目前越来越多的证据表明，二甲双胍除了具有降低血糖的作用外，还可降低糖尿病患者的癌症发生风险，先前的研究表明二甲双胍可以单独作用或与某些抗癌药物协同作用，通过腺苷单磷酸活化蛋白激酶(Adenosine 5'-monophosphate (AMP)-activated protein kinase，AMPK)信号通路对各种类型的肿瘤产生抗肿瘤作用。然而，二甲双胍对胃癌的抗肿瘤作用研究较少。本文结合国内外文献，介绍了二甲双胍在胃癌抗肿瘤作用中的不同机制，从基因、信号通路到对胃癌细胞系和胃癌干细胞的功能影响以及肿瘤细胞与肿瘤微环境之间的相互作用，并综述如下。
Abstract: At present, more and more evidence that metformin has the effect of lowering blood sugar; it also can reduce the cancer risk of diabetes. Previous research has shown that metformin may work alone or in combination with some anticancer drugs synergy, through single adenosine phosphate activated protein kinase (Adenosine 5'-monophosphate (AMP)-activated protein kinase, AMPK) signaling pathway having antitumor effects on various types of cancer. However, metformin re-search on antitumor effect of gastric cancer is less in this paper. Combined with domestic and for-eign literature, this paper introduces the metformin in different mechanisms of antitumor, gastric cancer from genes, signaling pathways to the function of gastric cancer cell lines and gastric cancer stem cells and the interaction between tumor cells and tumor microenvironment. And they summarized as follows.
文章引用：贺礼琴, 张双双, 冯义朝. 二甲双胍对胃癌抗肿瘤作用的研究进展[J]. 临床医学进展, 2019, 9(7): 831-836. https://doi.org/10.12677/ACM.2019.97128

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