小剂量盐酸羟考酮缓释片治疗中度癌痛的疗效观察

Observation of the Effect of Low-Dose Oxycodone Hydrochloride Prolonged-Release Tablets on the Treatment of Moderate Cancer Pain

摘要: 目的：探讨小剂量盐酸羟考酮缓释片治疗中度癌性疼痛的安全性及疗效。方法：55例中度癌痛患者接受盐酸羟考酮缓释片(10 mg q12h)治疗，观察止痛效果及不良反应。结果：治疗后NRS评分较治疗前下降明显，差异具有统计学意义(P < 0.05)；治疗后疼痛的客观总缓解率90.9%，其中完全缓解8例，部分缓解42例。不良反应主要为恶心、呕吐，便秘，头晕，排尿困难，发生率分别为16.4%，81.8%，20%，3.6%。结论：小剂量盐酸羟考酮缓释片治疗中度癌痛，患者安全、有效，不良反应低，对治疗中度癌痛的患者是很好的选择。

Abstract: Objective: To investigate the safety and efficacy of low-dose oxycodone hydrochloride prolonged- release tablets prolonged-release on the treatment of moderate cancer pain. Methods: 55 patients with moderate cancer pain were treated with oxycodone hydrochloride prolonged-release tablets (10 mg q12h). Results: The NRS score after treatment was significantly lower than that before treatment, and the difference was statistically significant (P < 0.05). The objective total rate of pain relief after treatment was 90.9%, including 8 cases of complete relief and 42 cases of partial relief. Adverse reactions were mainly nausea, vomiting, constipation, dizziness and dysuria, the incidence of which was 16.4%, 81.8%, 20% and 3.6%, respectively. Conclusion: Low-dose oxycodone hydrochloride prolonged-release tablet is safe and effective, and has low adverse reactions in the treatment of moderate cancer pain.