从胃泌素角度探讨针灸治疗慢性萎缩性胃炎的双向调节作用
Discussion from Gastrin on Bidirectional Regulating Effect of Acupuncture and Moxibustion on Chronic Atrophic Gastritis
DOI: 10.12677/TCM.2019.85050, PDF,    科研立项经费支持
作者: 李 峰, 刘雅楠, 黎 梅:上海中医药大学附属岳阳临床医学院,上海;吴焕淦, 王晓梅:上海市针灸经络研究所,上海
关键词: 慢性萎缩性胃炎胃泌素针灸双向调节Chronic Atrophic Gastritis Gastrin Acupuncture and Moxibustion Bidirectional Regulation
摘要: 慢性萎缩性胃炎作为一种临床的常见疾病,与胃癌的发生密切相关,目前没有有效的治愈办法。近年来针灸治疗慢性萎缩性胃炎的临床研究有一定的进展,疗效也较为肯定,但其具体机制众说纷坛。本文从胃泌素的角度探讨针灸治疗慢性萎缩性胃炎的具体机制,发现针灸对胃泌素的双向调节作用可能是其治疗慢性萎缩性胃炎的机制之一,为临床研究提供新的思路。
Abstract: Chronic atrophic gastritis is a common clinical disease, closely related to the occurrence of gastric cancer, and there is no effective cure at present. In recent years, acupuncture and moxibustion have made great progress in the clinical study on the treatment of chronic atrophic gastritis with satisfied clinical efficacy, but the mechanism is controversial. This article discussed the specific mechanism of acupuncture and moxibustion in treatment of chronic atrophic gastritis from gastrin. It was found that the bidirectional regulating effect of acupuncture and moxibustion on gastrin may be one of the mechanisms of acupuncture and moxibustion in treatment of chronic atrophic gastritis, providing a new idea for clinical research.
文章引用:李峰, 吴焕淦, 刘雅楠, 黎梅, 王晓梅. 从胃泌素角度探讨针灸治疗慢性萎缩性胃炎的双向调节作用[J]. 中医学, 2019, 8(5): 301-307. https://doi.org/10.12677/TCM.2019.85050

参考文献

[1] 房静远, 杜奕奇, 刘文忠, 等. 中国慢性胃炎共识意见(2017年, 上海) [J]. 胃肠病学, 2017, 37(11): 670-687.
[2] 韦信安. 慢性萎缩性胃炎的危险因素分析及其临床治疗[J]. 临床合理用药杂志, 2017, 10(36): 145-146.
[3] 钮萍萍, 张军, 戴利成, 等. 2015年浙江省湖州地区幽门螺杆菌常用抗生素耐药监测分析[J]. 生物技术通讯, 2016, 27(3): 441-443.
[4] Cheung, M.K., Wong, A.Y., Chen, L., et al. (2018) Long-Term Use of Proton Pump Inhibitors and Risk of Gastric Cancer Development after Treatment for, H. pylori: A Population-Based Study. Gut, 67, 28-35. [Google Scholar] [CrossRef] [PubMed]
[5] 张雪, 惠灿灿, 孙建然, 等. 胃泌素-17的临床研究进展[J]. 中国医药科学, 2018, 8(18): 29-33.
[6] Rehfeld, J.F., Friis-Hansen, L., Goetze, J.P., et al. (2007) The Biology of Cholecystokinin and Gastrin Peptides. Current Topics in Medicinal Chemistry, 7, 1154-1165. [Google Scholar] [CrossRef] [PubMed]
[7] 郭会玲, 高广周, 张金卓, 等. 中老年慢性非萎缩性胃炎患者血清胃蛋白酶原、胃泌素17水平变化[J]. 山东医药, 2018, 58(18): 50-52.
[8] Lorente, S., Doiz, O., Trinidad Serrano, M., et al. (2002) Helicobacter pylori Stimulates Pepsinogen Secretion from Isolated Human Peptic Cells. Gut, 50, 13-18. [Google Scholar] [CrossRef] [PubMed]
[9] 蔡惠美, 林晖, 欧希龙, 等. 联合胃蛋白酶原、胃泌素、粪便Hp抗原检测对萎缩性胃炎和胃癌的诊断价值[J]. 东南大学学报(医学版), 2018. 37(3): 406-410.
[10] Tucker, T.P., Gray, B.M., Eaton, K.A., et al. (2010) Helicobacter pylori Induction of the Gastrin Promoter through GC-Rich DNA Elements. Helicobacter, 15, 438-448. [Google Scholar] [CrossRef] [PubMed]
[11] Agréus, L., Storskrubb, T., Aro, P., et al. (2009) Clinical Use of Proton-Pump Inhibitors But Not H2-Blockers or Antacid/Alginates Raises the Serum Levels of Amidated Gastrin-17, Pepsinogen I and Pepsinogen II in a Random Adult Population. Scandinavian Journal of Gastroenterology, 44, 564-570. [Google Scholar] [CrossRef] [PubMed]
[12] 孟丽英. 萎缩性胃炎患者血清胃泌素-17及胃蛋白酶原水平检测及临床意义[J]. 山西医药杂志, 2018, 47(22): 60-62.
[13] 王亮亮. 慢性萎缩性胃炎临床诊断鉴别中胃泌素水平与胃蛋白酶原水平的联合检测效果观察[J]. 哈尔滨医药, 2017(4): 349-350.
[14] Agréus, L., Kuipers, E.J., Kupcinskas, L., et al. (2012) Rationale in Diagnosis and Screening of Atrophic Gastritis with Stomach-Specific Plasma Biomarkers. Scandinavian Journal of Gastroenterology, 47, 136-147. [Google Scholar] [CrossRef] [PubMed]
[15] 马曼茹, 李修岭, 丁松泽, 等. 空腹血清胃蛋白酶原和胃泌素-17对萎缩性胃炎的诊断价值[J]. 医药论坛杂志, 2018, 39(2): 17-20.
[16] 虞积耀, 王鲁平, 胡明. A型及B型萎缩性胃炎神经内分泌细胞的定量研究[J]. 第二军医大学学报, 1996(2): 154-156.
[17] Kikuchi, R., Abe, Y., Iijima, K., et al. (2011) Low Serum Levels of Pepsinogen and Gastrin 17 Are Predictive of Extensive Gastric Atrophy with High-Risk of Early Gastric Cancer. The Tohoku Journal of Experimental Medicine, 223, 35-44. [Google Scholar] [CrossRef] [PubMed]
[18] Copps, J., Murphy, R. and Lovas, S. (2009) The Production and Role of Gastrin-17 and Gastrin-17-Gly in Gastrointestinal Cancers. Protein & Peptide Letters, 16, 1504-1518. [Google Scholar] [CrossRef] [PubMed]
[19] 朱春平, 赵建业, 李兆申. 血清胃泌素G-17在慢性萎缩性胃炎诊断中的研究进展[J]. 国际消化病杂志, 2015(1): 31-34.
[20] 沈小军. 中医针灸疗法治疗慢性萎缩性胃炎的临床疗效[J]. 世界最新医学信息文摘, 2017, 17(25): 23-24.
[21] 徐旋. “金钩钓鱼”针法针刺华佗夹脊穴治疗慢性萎缩性胃炎的临床研究[D]: [硕士学位论文]. 兰州: 甘肃中医药大学, 2018: 57.
[22] 廖纬琳, 陈国忠, 胡辉, 等. 针灸治疗慢性萎缩性胃炎的Meta分析[J]. 世界华人消化杂志, 2014, 22(2): 233-238.
[23] 王坤, 唐纯志, 田小婷, 等. 基于数据挖掘技术针灸治疗慢性萎缩性胃炎选穴规律分析[J]. 中国中医基础医学杂志, 2018, 24(9): 98-101.
[24] Liu, C.C., Chen, J.L., Chang, X.R., et al. (2017) Comparative Metabolomics Study on Therapeutic Mechanism of Electro-Acupuncture and Moxibustion on Rats with Chronic Atrophic Gastritis (CAG). Scientific Reports, 7, Article No. 14362. [Google Scholar] [CrossRef] [PubMed]
[25] Liu, M., et al. (2011) Effects of Moxibustion on Gastric Mucosal EGF and TGF-α Contents and Epidermal Growth Factor Receptor Expression in Rats with Gastric Mucosal Lesion. Acupuncture Research, 36, 403-408.
[26] Yang, Z., Wang, C., Chen, J., et al. (2015) Effects of Moxibustion on Cell Proliferative Factors in Gastric Mucosa in Rats with Precancerous Lesions of Chronic Atrophic Gastritis. Chinese Acupuncture & Moxibustion, 35, 1269-1273.
[27] 舒文娜. 针刺、艾灸对慢性萎缩性胃炎大鼠胃黏膜COX-2及炎症细胞因子表达影响的对比研究[D]: [硕士学位论文]. 长沙: 湖南中医药大学, 2018: 49.
[28] 袁静, 高希言. 针灸治疗慢性萎缩性胃炎的临床研究[J]. 浙江中医杂志, 2006, 41(5): 263-264.
[29] Gao, X., Yuan, J., Li, H., et al. (2017) Clinical Research on Acupuncture and Moxibustion Treatment of Chronic Atrophic Gastritis. Journal of Traditional Chinese Medicine, 27, 87-91.
[30] 李璟, 李琪, 王硕硕, 等. 隔物灸法对慢性胃炎患者胃黏膜保护的临床效应研究[J]. 世界科学技术-中医药现代化, 2016, 18(3): 361-367.
[31] 谭惠斌. 利用fMRI成像与血清胃泌素水平变化对针刺足三里穴作用机制的研究[D]: [硕士学位论文]. 武汉: 湖北中医学院, 2009: 58.
[32] 赵彤彤. 针刺治疗慢性萎缩性胃炎的临床研究[D]: [硕士学位论文]. 武汉: 湖北中医学院, 2008: 42.
[33] 张迪, 袁星星, 王炳予, 等. 合募配穴灸法治疗慢性萎缩性胃炎临床观察[J]. 上海针灸杂志, 2017, 36(12): 1401-1405.
[34] 于隽, 孟庆玲, 张玉翠, 等. 电针内关穴对心律失常大鼠的双向调节作用及其中枢机制探讨[J]. 针灸临床杂志, 2013, 29(7): 77-81.
[35] 周思远. 针刺天枢穴双向调节肠道功能的中枢响应机制研究[D]: [博士学位论文]. 成都: 成都中医药大学, 2014: 117.
[36] 柳力公, 周吕, 张德华, 等. 针刺胃病患者胃窦部胃泌素细胞变化研究[J]. 针刺研究, 1994(2): 75-78.
[37] 王渊. 电针不同穴位对功能性肠病大鼠双向调节机制初探[D]: [博士学位论文]. 南京: 南京中医药大学, 2013: 126.