食管癌易感基因研究进展
The Research Progression of Susceptibility Gene on Esophageal Cancer
DOI: 10.12677/ACM.2019.910173, PDF,    科研立项经费支持
作者: 张冬云：南阳医学高等专科学校基础医学部，河南 南阳；库建伟：南阳医专二附院肿瘤内科，河南 南阳
关键词: 食管癌；全基因组关联分析；易感基因；遗传变异；Esophageal Cancer； Genome Wide Association Study； Susceptibility Gene； Genetic Variation
摘要: 全基因组关联分析是通过整个人类基因组来寻找常见遗传变异的可见性状间关系的研究方法。2010年来，通过对大样本量中国人群食管癌进行GWAS研究，研究者们相继发现了食管癌患者新的易感基因及变异SNPs。这些遗传变异不但存在累积作用而且其中一些变异以基因–环境交互作用方式共同增加食管癌发病风险。
Abstract: Genome-wide association study (GWAS) is a method of searching for the relationship between the visible traits of common genetic variation through the whole human genome. Researchers have discovered the new susceptibility genes and mutations of SNPs on esophageal cancer in large sample size of Chinese population by GWAS since 2010. Not only are these genetic variations cumulative, but some of them increase the risk of esophageal cancer in a gene-environment interaction.
文章引用：张冬云, 库建伟. 食管癌易感基因研究进展[J]. 临床医学进展, 2019, 9(10): 1129-1132. https://doi.org/10.12677/ACM.2019.910173

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