胃癌病理分期与长链非编码lncRNA表达的相关性研究
Study on the Correlation between Pathological Staging of Gastric Carcinoma and Expressions of Long-Chain Non-Coding lncRNA
DOI: 10.12677/WJCR.2019.94016, PDF,    科研立项经费支持
作者: 高希春, 钱 军*, 魏 铭, 徐星榕, 汪如荣, 辛向斌：河西学院附属张掖人民医院，甘肃 张掖
关键词: 胃癌；长链非编码RNA；lncRNA-19；FER1L4；LINC00152；AK054979；Gastric Cancer； Long Non-Coding RNA； lncRNA-19； FER1L4； LINC00152； AK054979
摘要: 目的：探讨长链非编码RNA(long noncoding RNA, lncRNA)中的lncRNA-19、FER1L4、LINC00152及AK054979在胃癌组织的表达。方法：收集24例胃癌患者癌组织，采用实时荧光定量PCR测定胃癌组织、癌旁组织及正常组织中lncRNA-19、FER1L4、LINC00152及AK054979的表达水平，分析lncRNA-19、FER1L4、LINC00152及AK054979表达与胃癌组织表达的相关性。结果：胃癌组织中lncRNA-19、FER1L4、LINC00152及AK054979的表达水平呈高表达(P均 < 0.01)；且与胃癌临床病理分期呈正相关(P < 0.05)。结论：lncRNA-19、FER1L4、LINC00152及AK054979在胃癌组织中均高表达，且与胃癌病理分期呈正相关。
Abstract: Objective: To explore the expression of lncRNA-19, FER1L4, LINC00152 and AK054979 in long noncoding RNA (lncRNA) in gastric carcinoma. Methods: We collected 24 cases gastric carcinoma tissues. The expression levels of lncRNA-19, FER1L4, LINC00152 and AK054979 in gastric carcinoma tissues, para-cancer tissues and normal tissues were measured by real-time fluorescence quantitative PCR, and the correlation between the expressions of lncRNA-19, FER1L4, LINC00152 and AK054979 and gastric carcinoma tissues was analyzed. Results: lncRNA-19, FER1L4, LINC00152 and AK054979 were highly expressed in gastric cancer tissues (P < 0.01). It was positively correlated with the clinical pathological stages of gastric carcinoma (P < 0.05). Conclusion: lncRNA-19, FER1L4, LINC00152 and AK054979 were all highly expressed in gastric carcinoma tissues and positively correlated with the pathological stages of gastric cancer.
文章引用：高希春, 钱军, 魏铭, 徐星榕, 汪如荣, 辛向斌. 胃癌病理分期与长链非编码lncRNA表达的相关性研究[J]. 世界肿瘤研究, 2019, 9(4): 110-117. https://doi.org/10.12677/WJCR.2019.94016

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