氨氯地平对高血压患者颈动脉粥样硬化的影响

Effects of Amlodipine on Carotid Atherosclerosis in Patients with Hypertension

摘要: 目的：进一步探讨氨氯地平对颈动脉粥样硬化的影响，为患者临床用药的选择提供理论依据。方法入选120名患者，实验组(60例服用氨氯地平5 mg/日)和对照组(60例，服用安慰剂5 mg/日)，分别测量初始、6个月、12个月患者的颈动脉超声情况。结果：1) 实验组与对照组比较，在性别、年龄、现在吸烟情况、体重指数(BMI)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、甘油三酯(TG)、空腹血糖、收缩压、舒张压、动脉粥样硬化斑块体积、劲动脉斑块厚度无统计学差异(p < 0.05)；2) 实验组颈动脉硬化斑块体积6个月(706.12 ± 90.08 mm³, p = 0.012)到12个月(427.84 ± 69.62 mm³, p < 0.001)，差异有统计学意义；相反，对照组中颈动脉硬化斑块体积6个月(793.63 ± 118.17 mm³, p = 0.964)到12个月(690.52 ± 136.57 mm³, p = 0.088)，差异无统计学意义；3) 实验组颈动脉硬化斑块厚度6个月(1.28 ± 0.13 mm, p = 0.379)到12个月(1.00 ± 0.13 mm, p < 0.000)；相反，对照组中颈动脉硬化斑块厚度6个月1.33 ± 0.12 mm, p = 0.652)到12个月(1.31 ± 0.13 mm3, p = 0.715)，差异无统计学意义。结论：发现氨氯地平在不影响血压的情况下，可降低劲动脉粥样硬化的发生。

Abstract: Objective: To further explore the effect of amlodipine on carotid atherosclerosis, and to provide a theoretical basis for the selection of clinical medication for patients. Methods: 120 patients were enrolled in the experimental group (60 patients taking amlodipine at 5 mg/day) and the control group (60 patients taking placebo at 5 mg/day). Carotid ultrasound was measured at the beginning, 6 months and 12 months, respectively. Results: 1) The experimental group compared with control group, now in gender, age, smoking, body mass index (BMI), total cholesterol (TC), low density lipo-protein (LDL), high-density lipoprotein (HDL), triglyceride (TG), fasting blood glucose, systolic pressure, diastolic blood pressure, atherosclerosis plaque volume, and the artery plaque thickness has no statistical difference (p < 0.05); 2) The carotid plaque volume in the experimental group ranged from 6 months (706.12 ± 90.08 mm³, p = 0.012) to 12 months (427.84 ± 69.62 mm³, p < 0.001), and the difference was statistically significant. In contrast, carotid plaque volume in the control group ranged from 6 months (793.63 ± 118.17 mm³, p = 0.964) to 12 months (690.52 ± 136.57 mm³, p = 0.088), with no statistically significant difference; 3) The thickness of carotid plaque in the experimental group ranged from 6 months (1.28 ± 0.13 mm, p = 0.379) to 12 months (1.00 ± 0.13 mm, p < 0.000). In contrast, carotid plaque thickness in the control group ranged from 1.33 ± 0.12 mm (p = 0.652) to 12 months (1.31 ± 0.13 mm3, p = 0.715), with no statistically significant difference. Conclusion: Amlodipine can reduce the incidence of atherosclerosis without affecting blood pressure.