异种脱细胞真皮基质预防Frey综合征的远期效果研究

Study on the Long-Term Effect of Heterogeneous Acellular Allograft Dermal Matrix in the Prevention of Frey’s Syndrome

摘要: 目的：研究应用腮腺嚼肌筋膜及异种脱细胞真皮基质预防腮腺术后Frey综合征的远期效果。方法：将2008~2015年在天津医科大学总医院口腔颌面外科因患腮腺肿瘤接受腮腺切除术的患者285例分为3组：1组：92例患者采用常规术式，2组：96例患者采用保留腮腺嚼肌筋膜术式；3组：97例患者采用应用异种脱细胞真皮基质术式。结果：术后1年Frey综合征发生，1组和2、3组比较有显著统计学差异(P < 0.05)，2、3组比较无明显统计学差异(P > 0.05)。术后2年1组和2、3组比较有显著统计学差异(P < 0.05)，2、3组比较有显著统计学差异(P < 0.05)。结论：保留腮腺咬肌筋膜可以明显降低Frey综合征的发生，异种脱细胞真皮基质短期内可以明显降低Frey综合征的发生，但长期效果较差。

Abstract: Objective: To study the long-term effect of parotid fascia and heterogeneous acellular allograft dermal matrix to prevent Frey’s syndrome after parotidectomy. Methods: The 285 cases of patients in Tianjin Medical University General Hospital of oral and maxillofacial surgery from 2008 to 2015 with parotid tumors accepted parotid resection were divided into 3 groups: Group 1: 92 cases were treated by routine operation; Group 2: 96 cases were treated with retaining parotid fascia in operation; Group 3: 97 patients were treated with application of heterogeneous acellular allograft dermal matrix in operation. Results: After one year of operation, there were significant statistical differences between group 1 and group 2, 3 (P < 0.05); group 2 and group 3 had no significant statistical difference (P > 0.05). After 2 years of operation, group 1 and group 2, 3 were significantly statistical different (P < 0.05); group 2 and group 3 had significant statistical difference (P < 0.05). Conclusion: It shows that the parotid fascia can significantly reduce the incidence of Frey’s syndrome; heterogeneous acellular allograft dermal matrix can significantly reduce the incidence of Frey’s syndrome in the short term, but the long-term effect is poor.