谷氨酸脱氢酶的基本特性及其抑制剂的相关研究进展
The Basic Characteristics of Glutamate Dehydrogenase and Its Inhibitors
DOI: 10.12677/PI.2019.86026, PDF,   
作者: 叶恒宇, 侯 卫, 阮奔放*：浙江工业大学药学院，浙江 杭州
关键词: 谷氨酸脱氢酶；特性；癌症；抑制剂；Glutamate Dehydrogenase； Characteristics； Cancer； Inhibitor
摘要: 谷氨酸脱氢酶(GDH)位于动植物以及微生物体内的线粒体中，对于三羧酸循环的能量代谢、细胞内氧化还原平衡、氨含量的稳态维持和信号转导的调控起着至关重要的作用。但它的调控因子较多，易发生突变，从而导致一些疾病的产生，如癌症、高胰岛素–高血氨综合征、帕金森病等。因此，针对GDH抑制剂的研究具有很大的开发潜力和应用前景。但有关GDH抑制剂的文献综述尚未见报道。本文根据GDH抑制剂的结构类型，综述了一些具有代表性的GDH抑制剂的研究进展，包括多酚类、含氯硫类、间苯二甲酸类、甾体激素类以及新型硒啉类等化合物。表明深入研究GDH及其有效的抑制剂对于治疗相关疾病具有很好的发展前景。
Abstract: Glutamate dehydrogenase (GDH) is located in mitochondria of animals, plants and microorganisms, and plays a vital role in energy metabolism of tricarboxylic acid cycle, intracellular redox balance, stable maintenance of ammonia content and regulation of signal transduction. However, it has many regulatory factors and is prone to mutation, which leads to some diseases, such as cancer, hyperinsulinemia-hyperammonemia syndrome, Parkinson’s disease, etc. Therefore, the research on GDH inhibitors has great development potential and application prospect. However, the literature review on GDH inhibitors has not been reported. According to the structural types of GDH inhibitors, this paper reviews the research progress of some representative GDH inhibitors, including polyphenols, chlorine and sulfur compounds, isophthalic acids, steroid hormones and new selens. It shows that indepth study of GDH and its effective inhibitors has a good development prospect for the treatment of related diseases.
文章引用：叶恒宇, 侯卫, 阮奔放. 谷氨酸脱氢酶的基本特性及其抑制剂的相关研究进展[J]. 药物资讯, 2019, 8(6): 195-201. https://doi.org/10.12677/PI.2019.86026

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