北缬草挥发油镇静作用的研究

Study on Sedative Effect of Volatile Oils from Valeriana fauriei Briq.

摘要: 目的：研究北缬草挥发油的镇静作用，为北缬草挥发油的临床应用提供依据。方法：将40只雄性ICR小鼠随机分为空白对照组、高剂量组、低剂量组，每组10只。空白对照组按12 mL/Kg灌胃1% Tween-80水溶液，高剂量组、中剂量组、低剂量组分别给予北缬草挥发油0.80 g/Kg、0.40 g/Kg、0.20 g/Kg，观察北缬草挥发油对小鼠自主活动的影响以及在戊巴比妥钠协同下对小鼠睡眠时间的影响。结果：高剂量组、中剂量组、低剂量组北缬草挥发油均能显著减少小鼠自主活动的次数，高剂量组明显低于空白对照组(P < 0.01)。与空白对照组相比，三组的挥发油均能增加戊巴比妥钠致小鼠入睡只数，显著延长小鼠的睡眠时间，高剂量组明显高于空白对照组(P < 0.01)。结论：北缬草挥发油对小鼠有明显的镇静作用。

Abstract: Objective: To study the sedative effect of volatile oils from Valeriana fauriei Briq., and provide the basis for clinical application. Methods: 40 male ICR mice were randomly divided into four groups: the blank control group, the high dose group, the middle dose group and the low dose group, 10 mice in each group. The blank control group was given 12 mL/Kg 1% water solution of Tween-80; the high dose group, the middle dose group and the low dose group were given the volatile oils from Valeriana fauriei Briq. 0.80 g/Kg, 0.40 g/Kg, 0.20 g/Kg; the spontaneous activity and the sleep time of mice were observed. Results: Volatile oils from Valeriana fauriei Briq. of the high dose group, the middle dose group and the low dose group can significantly reduce the number of spontaneous activity of mice; the high dose group was significantly lower than the control group (P < 0.01). Compared with the blank control group, volatile oil of the high dose group, the middle dose group and the low dose group can increase the number of sleeping mice and significantly prolong the sleep time of mice induced by sodium pentobarbital; the high dose group was significantly higher than the control group (P < 0.01). Conclusion: Volatile oils from Valeriana fauriei Briq. has a sedative effect on the mice.