麝香通心滴丸对冠状动脉慢血流的改善作用

Effect of Shexiang Tongxin Dropping Pills on Coronary Slow Flow

摘要: 目的：探索麝香通心滴丸对冠状动脉慢血流患者的临床作用。方法：选择2018年3月至2019年2月因心绞痛就诊于我院并通过冠状动脉造影确诊为冠状动脉慢血流的70例住院患者，随机分为麝香通心滴丸组(35例)和对照组(35例)。两组均按照冠心病诊疗常规予以抗血小板、抗动脉硬化等治疗，麝香通心滴丸组在上述基础上加服麝香通心滴丸(冠脉造影术中即刻舌下含服175 mg，造影术后口服70 mg tid，连续服用6月)。造影术中测定含服麝香通心滴丸前及含服5分钟后患者的冠状动脉微循环阻力指数(Index of microcirculatory resistance，IMR)，术前及连续服药6个月后应用加拿大心血管病学会(CCS)心绞痛分级及西雅图心绞痛量表(SAQ)评估两组患者治疗前后心绞痛严重程度及评分。结果：两组患者治疗前的CCS分级、SAQ评分、IMR值的差异无统计学意义(P < 0.05)。患者含服麝香通心滴丸5分钟后其IMR值(27.9 ± 7.7)较含服前(30.7 ± 5.6)明显改善(P < 0.05)，也明显低于对照组(30.9 ± 4.8)，差距有统计学意义(P < 0.05)；两组患者治疗6个月后的CCS分级降低(P < 0.05)，SAQ评分升高(P < 0.05)，且上述指标麝香通心滴丸组患者的改善效果较对照组更为显著(P < 0.05)。结论：麝香通心滴丸可改善冠状动脉慢血流患者的微血管功能并明显减少心绞痛的发作。

Abstract: Objective: To explore the clinical impact of Shexiang Tongxin dropping pills (STDP) on patients with coronary slow flow (CSF). Methods: From March 2018 to February 2019, 70 inpatients with angina pectoris who were admitted to our hospital and diagnosed with CSF by coronary angiography were randomly divided into the STDP group (35 cases) and the control group (35 cases). Both groups were treated with anti-platelet and anti-arteriosclerosis according to the routine of coronary heart disease diagnosis and treatment, and the STDP group was given STDP on the above basis (175 mg was taken sublingually immediately during coronary angiography, and 70 mg tid was taken orally after angiography for 6 months). Index of microcirculatory resistance (IMR) was measured before and after 5 minutes of sublingual administration during coronary angiography. The severity and score of angina pectoris before and after treatment were assessed by the Canadian Cardiovascular Society (CCS) angina grading and Seattle Angina Questionnaire (SAQ). Results: There was no significant difference in CCS grade, SAQ score, IMR value between the two groups before treatment (p < 0.05). The IMR value (27.9 ± 7.7) was significantly improved 5 minutes after sublingual STDP than before the administration (30.7 ± 5.6) (P < 0.05) and also significantly lower than that in the control group (30.9 ± 4.8) (p < 0.05). The CCS grade was decreased (p < 0.05) and the SAQ score was increased (p < 0.05) in the two groups after 6 months of treatment. Moreover, the improvement effect of the above index was more significant in the patients with STDP group than in the control group (p < 0.05). Conclusions: Shexiang Tongxin drop pills can improve the microvascular function of patients with slow coronary blood flow and significantly reduce the attack of angina pectoris.