基于mRNA表达谱比较胃癌和房颤的分子生物特征

Comparing the Molecular Biological Characteristics between Gastric Cancer and Atrial Fibrillation Based on mRNA Expression Profiles

摘要: 有研究显示，新发房颤患者的癌症风险显著增加，新发癌症患者的房颤风险也有所增加，说明两种疾病之间可能存在一定的联系。传统上，有关癌症和房颤的机制研究大多是独立开展的。本研究以胃癌为例，基于mRNA表达谱，采用生物信息学工具比较分析胃癌与房颤在分子水平上的生物特征，为癌症与房颤共病的机制研究提供一定的理论基础。首先从mRNA表达谱中分别筛选胃癌与房颤相关的差异表达mRNAs，再采用差异表达mRNAs分别富集胃癌与房颤的生物特征；然后通过分别构建胃癌与房颤的蛋白质–蛋白质相互作用网络，识别胃癌与房颤相关的重要靶向分子；最后，比较与分析胃癌与房颤在分子水平上的联系。研究结果表明，胃癌与房颤有一些相同的分子生物特征，二者相关的重要靶向分子也存在一定联系。

Abstract: Some researches have shown that there was a significant increase in cancer risk in patients with new onset atrial fibrillation (AF), and there is also an increased risk of AF in new cancer patients. It suggests that there may be a relationship between the two diseases. Traditionally, the study on mechanisms of cancer and atrial fibrillation has been conducted independently. Based on mRNA expression profiles and by using bioinformatics tools, this study selected gastric cancer (GC) and AF as the objects of study, compared and analyzed the biological characteristics of GC and AF at the molecular level so as to provide a theoretical basis for the study on the mechanism of comorbidity between cancer and AF. Firstly, differentially expressed mRNAs associated with GC and AF were screened from mRNA expression profiles respectively, and then biological characteristics of GC and AF were enriched using differentially expressed mRNAs. Secondly, some key targeting molecules related to GC and AF were identified from protein-protein interaction networks of them, re-spectively. Finally, we compared and analyzed the relationships at the molecular level between GC and AF. The results showed that GC and AF have some of the same molecular biological character-istics. There is also a certain relationship between the two key targeting molecules.