白藜芦醇诱导前列腺肿瘤细胞凋亡机制研究进展

Mechanism of Resveratrol Induced Apoptosis in Prostate Cancer Cells

摘要: 前列腺癌在美国男性中发病率最高，近年来在中国发病率也逐年上升，成为威胁男性健康的重要因素。虽然目前可以通过手术治疗、放疗化疗和内分泌治疗缓解，但是一旦转为激素难治性前列腺癌后对内分泌治疗不敏感，愈后较差，死亡率高，迫切需要替代治疗方法和药物。白藜芦醇是一种广泛存在于葡萄、花生等红色果皮中的多酚化合物，被证明具有良好的抗癌功效，对前列腺癌细胞具有显著的抑制作用，但对正常细胞的生长几乎无影响，因此是一种比较理想的抗前列腺癌药物。该文从白藜芦醇诱导前列腺癌细胞凋亡的机制进行概述，为其今后的研究和临床应用提供参考。

Abstract: Prostate cancer has the highest incidence among men in the United States. In recent years, the in-cidence of prostate cancer has increased in China, which has become an important threat to men's health. Although it can be alleviated by surgery, radiotherapy, chemotherapy and endocrine ther-apy at present, it is not sensitive to endocrine therapy once it turns to hormone refractory prostate cancer. The prognosis is poor with high mortality, so there is an urgent need for alternative therapies and drugs. Resveratrol is a kind of polyphenol compound widely existing in red peel of grape, peanut and so on. It has been proved that resveratrol has a good anti-cancer effect, has a significant inhibitory effect on prostate cancer cells, but has little effect on the growth of normal cells. Therefore, it is an ideal anti-prostate cancer drug. This paper reviews the mechanism of resveratrol induced apoptosis of prostate cancer cells, and provides reference for its future research and clinical application.