肝再生分子机制的研究进展

Molecular Mechanisms of Research on Liver Regeneration

摘要: 肝再生是肝脏受到损伤刺激时一个高度组织化的组织再生过程，临床上，肝部分切除术(PHx)、肝脏移植、肝炎的治疗都需要依赖肝脏再生机制进行修复。肝再生分为三个阶段：启动阶段、增殖阶段和终止阶段，在不同的阶段由不同的分子参与。目前，肝脏再生的分子机制以及寻找促进肝再生的药物已成为科研人员研究的热点，本文将从细胞因子、生长因子和信号通路等方面对肝脏再生的机制进行综述，为肝再生药物治疗的临床研究提供有价值的研究信息。

Abstract: Liver regeneration is a highly organized tissue regeneration process when the liver is stimulated by injury. Partial hepatectomy (PHx), liver transplantation, and treatment of hepatitis all depend on the liver regeneration mechanism for repair in clinic. Liver regeneration is divided into three stages: the priming phase, the proliferation phase and the termination phase with different molecules participating in different stages. At present, the molecular mechanism and the search for drugs of liver regeneration have become hotspots for scientific researchers. This article will review the mechanisms of liver regeneration from cytokines, growth factors and signaling pathways, and provide a clinical basis for liver regeneration medicine. The research provides valuable research information.