非小细胞肺癌与甲状腺激素关系的探讨
Study on the Relationship between Non-Small Cell Lung Cancer and Thyroid Hormone
摘要: 肺癌是全球最常见的恶性肿瘤之一,发病率和死亡率呈逐年上升趋势。提高肺癌患者生存率的关键在于早发现,早诊断,早治疗。大量证据表明甲状腺功能的改变与恶性肿瘤,特别是乳腺癌之间存在相互作用关系。然而,甲状腺功能与肺癌是否有相关性,目前研究未明确,有关文献报道,许多非甲状腺疾病患者,特别是一些恶性肿瘤患者,其甲状腺激素(Thyroid hormone, TH)水平可能会发生变化。本文结合国内外相关研究进展,对非小细胞肺癌(non-small cell lung cancer, NSCLC)患者与甲状腺激素水平的相关性做一综述,为临床评估NSCLC患者的病情及临床预后提供参考。
Abstract: Lung cancer is one of the most common malignant tumors in the world. Morbidity and mortality are on the rise year by year. The key to improve the survival rate of lung cancer patients is early detection, early diagnosis and early treatment. In recent years, a large number of indirect evidences have shown that there is an interaction between thyroid function and malignant diseases, especially breast carcinoma. However, the association between thyroid function and lung cancer has only been reported occasionally. It has been reported in the literature that the level of Thyroid hormone (TH) may change in many patients with non-thyroid diseases, especially in some patients with malignant tumors. Thyroid hormone may play a role in diseases other than hyperthyroidism and hypothyroidism. This article reviews the correlation between thyroid hormone levels and non-small cell lung cancer (NSCLC) patients, in order to provide reference for clinical evaluation of the condition and prognosis of NSCLC patients, and to guide clinical treatment.
文章引用:赵晓军, 严桥路, 何连福. 非小细胞肺癌与甲状腺激素关系的探讨[J]. 临床医学进展, 2020, 10(3): 191-196. https://doi.org/10.12677/ACM.2020.103031

参考文献

[1] 苟云久, 于珺, 何晓东, 谢定雄, 赵静. 肺癌与血清甲状腺激素水平关系的Meta分析[J]. 临床荟萃, 2014, 29(12): 1355-1361.
[2] 高士豪, 王章站. 电视胸腔镜手术与传统手术相比治疗非小细胞肺癌患者对其心肺功能的影响[J]. 健康大视野, 2020(1): 58-59.
[3] 刘艳琰. 非小细胞肺癌患者化疗前后血清甲状腺激素水平变化分析[J]. 中国实用医刊, 2015, 42(7): 117-118.
[4] 葛均波, 徐永健. 内科学[M]. 第8版. 北京: 人民卫生出版社, 2014.
[5] 朱大年, 王庭槐. 生理学[M]. 第8版. 北京: 人民卫生出版社, 2013.
[6] Gonzalez-Sancho, J.M., García, V., Bonilla, F., et al. (2003) Thyroid Hormone Receptors/THR Genes in Human Cancer. Cancer Letters, 192, 121-132. [Google Scholar] [CrossRef
[7] Aranda, A., Martínez-Iglesias, O., Ruiz-Llorente, L., et al. (2009) Thyroid Receptor: Roles in Cancer. Trends in Endocrinology and Metabolism, 20, 318-324. [Google Scholar] [CrossRef] [PubMed]
[8] Bailey, E.B.,Tantravahi, S.K., Poole, A., et al. (2015) Correlation of Degree of Hypothyroidism with Survival Outcomes in Patients with Metastatic Renal Cell Carcinoma Receiving Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors. Clinical Genitourinary Cancer, 13, 131-137. [Google Scholar] [CrossRef] [PubMed]
[9] Hellevik, A.I., Asvold, B.O., Bj?ro, T., et al. (2009) Thyroid Function and Cancer Risk: A Prospective Population Study. Cancer Epidemiology, Biomarkers & Prevention, 18, 570-574. [Google Scholar] [CrossRef
[10] Mazzoccoli, G., Pazienza, V., Piepoli, A., et al. (2012) Al-teration of Hypothalamic-Pituitary-Thyroid Axis Function in Non-Small-Cell Lung Cancer Patients. Integrative Cancer Therapies, 11, 327-336. [Google Scholar] [CrossRef] [PubMed]
[11] Cabodi, S., del Pilar Camacho-Leal, M., Di Stefano, P., et al. (2010) Integrin Signalling Adaptors: Not Only Figurants in the Cancer Story. Nature Reviews. Cancer, 10, 858-870. [Google Scholar] [CrossRef] [PubMed]
[12] Desgrosellier, J.S. and Cheresh, D.A. (2010) Integrins in Cancer: Biological Implications and Therapeutic Opportunities. Nature Reviews. Cancer, 10, 9-22. [Google Scholar] [CrossRef] [PubMed]
[13] Belmadani, S., Zerfaoui, M., Boulares, H.A., et al. (2008) Microvessel Vascular Smooth Muscle Cells Contribute to Collagen Type I Deposition through ERK1/2 MAP Kinase, Alpha V Be-ta3-Integrin, and TGF-Beta1 in Response to ANG II and High Glucose. American Journal of Physiology. Heart and Circulatory Physiology, 295, 69-76. [Google Scholar] [CrossRef] [PubMed]
[14] Cai, W. and Chen, X. (2006) Anti-Angiogenic Cancer Therapy Based on Integrin Alpha v Beta3 Antagonism. Anti-Cancer Agents in Medicinal Chemistry, 6, 407-428. [Google Scholar] [CrossRef] [PubMed]
[15] Arnaout, M.A., Goodman, S.L. and Xiong, J.P. (2007) Struc-ture and Mechanics of Integrin-Based Cell Adhesion. Current Opinion in Cell Biology, 19, 495-507. [Google Scholar] [CrossRef] [PubMed]
[16] Byzova, T.V., Goldman, C.K., Pampori, N., et al. (2000) A Mechanism for Modulation of Cellular Responses to VEGF: Activation of the Integrins. Molecular Cell, 6, 851-860. [Google Scholar] [CrossRef
[17] Bergh, J.J., Lin, H.Y., Lansing, L., et al. (2005) Integrin aVb3 Contains a Cell Surface Receptor Site for Thyroid Hormone that Is Linked to Activation of Mitogen-Activated Protein Kinase and Induction of Angiogenesis. Endocrinology, 146, 2864-2871. [Google Scholar] [CrossRef] [PubMed]
[18] Meng, R., Tang, H.Y., Westfall, J., et al. (2011) Crosstalk between Integrin αvβ3 and Estrogen Receptor-α Is Involved in Thyroid Hormone-Induced Proliferation in Human Lung Carci-noma Cells. PLoS ONE, 6, 27547. [Google Scholar] [CrossRef] [PubMed]
[19] Davis, P.J., Davis, F.B., Mousa, S.A., et al. (2011) Membrane Receptor for Thyroid Hormone: Physiologic and Pharmacologic Implications. Annual Review of Pharmacology and Toxicology, 51, 99-115. [Google Scholar] [CrossRef] [PubMed]
[20] Moeller, L.C., Dumitrescu, A.M. and Refetoff, S. (2005) Cytosolic Action of Thyroid Hormone Leads to Induction of Hypoxia-Inducible Factor-1α and Glycolytic Genes. Molecular Endocrinology, 19, 2955-2963. [Google Scholar] [CrossRef] [PubMed]
[21] Lin, H.Y., Sun, M., Tang, H.Y., et al. (2009) L-Thyroxine vs. 3,5,3’-Triiodo-L-Thyronine and Cell Proliferation: Activation of Mitogen-Activated Protein Kinase and Phosphatidyl-inositol 3-Kinase. American Journal of Physiology. Cell Physiology, 296, C980-C991. [Google Scholar] [CrossRef] [PubMed]
[22] Moeller, L.C. and Führer, D. (2013) Thyroid Hormone, Thyroid Hormone Receptors, and Cancer: A Clinical Perspective. Endocrine-Related Cancer, 20, 19-29. [Google Scholar] [CrossRef
[23] Lin, H.Y., Su, Y.F., Hsieh, M.T., et al. (2013) Nuclear Monomeric Integrin αv in Cancer Cells Is a Coactivator Regulated by Thyroid Hormone. The FASEB Journal, 27, 3209-3216. [Google Scholar] [CrossRef] [PubMed]
[24] Lin, H.Y., Cody, V., Davis, F.B., et al. (2011) Identification and Functions of the Plasma Membrane Receptor for Thyroid Hormone Analogues. Discovery Medicine, 11, 337-347.
[25] Cody, V., Davis, P.J. and Davis, F.B. (2007) Molecular Modeling of the Thyroid Hormone Interactions with Alpha v Beta 3 Integrin. Steroids, 72, 165-170. [Google Scholar] [CrossRef] [PubMed]
[26] Kress, E., Samarut, J. and Plateroti, M. (2009) Thyroid Hormones and the Control of Cell Proliferation or Cell Differentiation: Paradox or Duality? Molecular and Cellular Endocrinology, 313, 36-49. [Google Scholar] [CrossRef] [PubMed]
[27] Lin, H.Y., Chin, Y.T., Nana, A.W., et al. (2016) Actions Oef l-Thyroxine and Nano-Diamino-Tetrac (Nanotetrac) on PD-L1 in Cancer Cells. Steroids, 114, 59-67. [Google Scholar] [CrossRef] [PubMed]
[28] Lin, H.Y., Glinsky, G.V., Mousa, S.A., et al. (2015) Thyroid Hormone and Anti-Apoptosis in Tumor Cells. Oncotarget, 6, 14735-14743. [Google Scholar] [CrossRef] [PubMed]
[29] Mazzoccoli, G., Pazienza, V., Piepoli, A., et al. (2012) Alteration of Hypothalamic-Pituitay-Thyroid Axis Function in Non-Small Cell Lung Cancer Patients. Integrative Cancer Therapies, 11, 327-336. [Google Scholar] [CrossRef] [PubMed]
[30] 薛荣梅, 葛伟. 肺癌患者血清甲状腺激素的变化及临床意义[J]. 现代肿瘤医学, 2015, 23(8): 1081-1083.
[31] 李红燕, 王少芳, 王龙. 非小细胞肺癌患者化疗前后血清甲状腺激素水平的变化[J]. 中国临床研究, 2015, 28(9): 1131-1134.
[32] 王长江, 许卫国. 甲状腺激素与N末端脑钠肽前体对非小细胞肺癌的诊断价值[J]. 国际检验医学杂志, 2019, 40(17): 2107-2111.
[33] Chopra, I.J. (1997) Clinical Review 86 Euthyroid Sick Syndrome: Is It a Misnomer? The Journal of Clinical Endocrinology and Metabolism, 82, 329-334. [Google Scholar] [CrossRef] [PubMed]
[34] Moeller, L.C. and Führer, D. (2013) Thyroid Hormone, Thyroid Hormone Receptors, and Cancer: A Clinical Perspective. Endocrine-Related Cancer, 20, 19-29. [Google Scholar] [CrossRef
[35] Garfield, D.H., Wolter, P., Sch?ffski, P., et al. (2008) Documentation of Thyroid Function in Clinical Studies with Sunitinib: Why Does It Matter. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 26, 5131-5132. [Google Scholar] [CrossRef
[36] Khan Samer, R., Layal, C., Rikje, R., et al. (2016) Thyroid Function and Cancer Risk: The Rotterdam Study. The Journal of Clinical Endocrinology and Metabolism, 101, 5030-5036. [Google Scholar] [CrossRef] [PubMed]