血管性痴呆动物模型及病理机制研究进展
Research Progress of Vascular Dementia in Animal Model and Pathology
DOI: 10.12677/PI.2020.92011, PDF,    国家自然科学基金支持
作者: 王红艳, 陈 晨, 吴 莎, 郑昌博, 翁稚颖*, 杨为民*：昆明医科大学药学院暨云南省天然药物药理重点实验室，云南 昆明；何海艳, 王玉川：昭通市天麻研究院，云南 昭通
关键词: 血管性痴呆；动物模型；机制；Vascular Dementia； Animal Model； Mechanism
摘要: 血管性痴呆(VaD)是由多种脑血管疾病导致的脑部慢性供血不足所形成的一种慢性、渐进性的脑部疾病，属于老年痴呆的一种。近年来，该病发病率呈上升趋势，但是该病的发病机制仍尚未明确，也无特效药的治疗。建立一种能较好模拟VaD的动物模型，对该病的发病机制，病理研究具有重要意义。此外，本文还介绍了几种与VaD相关的病理机制，以期为研究该疾病的潜在药物提供研究思路。
Abstract: Vascular dementia (VaD) is a chronic, progressive brain disease caused by chronic blood supply to the brain because of a variety of cerebrovascular diseases; it is a type of senile dementia. In recent years, the incidence of the disease is on the rise, but the pathogenesis of the disease is still unclear, and there are no specific drugs to treat it. Establishing an animal model that can simulate VaDbet-ter is of great significance for the pathogenesis and pathological study of the disease. In addition, this article also introduces several pathological mechanisms related to VaD, in order to provide research ideas of potential drugs for the disease.
文章引用：王红艳, 何海艳, 王玉川, 陈晨, 吴莎, 郑昌博, 翁稚颖, 杨为民. 血管性痴呆动物模型及病理机制研究进展[J]. 药物资讯, 2020, 9(2): 71-77. https://doi.org/10.12677/PI.2020.92011

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