儿童急性淋巴细胞白血病合并可逆性后部脑病综合征2例并文献复习
Acute Lymphoblastic Leukemia with Posterior Reversible Encephalopathy Syndrome in Children: A Report of 2 Cases and Literature Review
DOI: 10.12677/ACRP.2020.82003, PDF,   
作者: 张 雷：南方医科大学，广东 广州；吴学东：南方医科大学南方医院，广东 广州
关键词: 可逆性后部脑病综合征；急性淋巴细胞白血病；儿童；Posterior Reversible Encephalopathy Syndrome； Acute Lymphoblastic Leukemia； Children
摘要: 目的：提高对儿童急性淋巴细胞白血病合并可逆性后部脑病综合征的认识。方法：回顾分析南方医院收治的2名急性淋巴细胞白血病合并可逆性后部脑病综合征的临床资料，并结合文献进行分析。结果：2名患儿在急性淋巴细胞白血病治疗过程中出现意识障碍、高血压、抽搐等症状。头颅MRI显示双侧顶、枕、颞叶皮层或皮层下长T2信号。经过降压等对症处理后症状缓解。结论：PRES发病机制是多方面的，早期诊断、早期治疗可使病情在短期内逆转。
Abstract: Objective: To improve recognition of acute lymphoblastic leukemia with posterior reversible en-cephalopathy syndrome in children. Method: Two ALL children with PRES admitted to Nanfang Hospital were included. Clinical data were retrospectively studied and related literatures were re-viewed. Result: During the treatment of acute lymphoblastic leukemia, 2 children developed symptoms of consciousness disorder, hypertension and convulsion. Cranial MRI showed bilateral parietal, temporal and occipital cortical or subcortical lesions with hypointensity on T2-weighted imaging. Clinical symptoms were resolved soon after supportive care such as anti-hypertension. Conclusion: The pathogenesis of PRES is multifaceted. Early diagnosis and treatment are very im-portant.
文章引用：张雷, 吴学东. 儿童急性淋巴细胞白血病合并可逆性后部脑病综合征2例并文献复习[J]. 亚洲儿科病例研究, 2020, 8(2): 13-17. https://doi.org/10.12677/ACRP.2020.82003

参考文献

[1] Fischer, M. and Schmutzhard, E. (2017) Posterior Reversible Encephalopathy Syndrome. Journal of Neurology, 264, 1608-1616.
[Google Scholar] [CrossRef] [PubMed]
[2] Liu, J. and Qin, J. (2016) Research Advances of Posterior Reversible Encephalopathy Syndrome in Children. Chinese Journal of Contemporary Pediatrics, 18, 787-791.
[3] Wang, Q.L., Huang, B., Shen, G.Q., et al. (2019) Blood-Brain Barrier Disruption as a Potential Target for Therapy in Posterior Reversible Encephalopathy Syndrome: Evidence from Multimodal MRI in Rats. Frontiers in Neurology, 10, 1211.
[Google Scholar] [CrossRef] [PubMed]
[4] Khan, S.J., Arshad, A.A., Fayyaz, M.B., et al. (2018) Posterior Reversible Encephalopathy Syndrome in Pediatric Cancer: Clinical and Radi-ologic Findings. Journal of Global Oncology, 4, 1-8.
[Google Scholar] [CrossRef] 
[5] Musiol, K., Waz, S., Boroń, M., et al. (2018) PRES in the Course of Hemato-Oncological Treatment in Children. Child’s Nervous System, 34, 691-699.
[Google Scholar] [CrossRef] [PubMed]
[6] Khan, R.B., Sadighi, Z.S., Zabrowski, J., et al. (2016) Imaging Patterns and Outcome of Posterior Reversible Encephalopathy Syndrome during Childhood Cancer Treatment. Pediatric Blood & Cancer, 63, 523-526.
[Google Scholar] [CrossRef] [PubMed]
[7] Zou, L.P., Liu, L.Y., Li, H., et al. (2019) Establishment and Utility Assessment of Posterior Reversible Encephalopathy Syndrome Early Warning Scoring (PEWS) Scale Establishment and Utility Assessment of PEWS Scale. BMC Neurology, 19, Article number: 30.
[Google Scholar] [CrossRef] [PubMed]
[8] Fugate, J.E. and Rabinstein, A.A. (2015) Posterior Reversible Encephalopathy Syndrome: Clinical and Radiological Manifestations, Pathophysiology, and Outstanding Questions. The Lancet Neurology, 14, 914-925.
[Google Scholar] [CrossRef]