快速眼动睡眠期行为障碍相关的帕金森病的影像学生物标志研究进展
Progress in the Study of Imaging Biomarkers of Parkinson’s Disease with REM Sleep Behaviour Disorder
摘要: 快速眼动睡眠期行为障碍(REM sleep behaviour disorder, RBD)是一种发生在快速眼动期(rapid eye movement, REM)的一种与梦境相关的复杂行为障碍，特发性快速眼动睡眠期行为障碍(idiopathic RBD, iRBD)与神经变性病如帕金森病(Parkinson’s disease, PD)、路易体痴呆(dementia with Lewy bodies, DLB)、多系统萎缩(multiple system atrophy, MSA)等密切相关，其中帕金森病最多见。iRBD是神经变性病的前驱症状。尽早发现并干预神经变性病显得尤为重要。当前许多研究致力于寻找RBD相关的神经变性病的生物学标志，其中影像学方面的技术因其客观性和快速进展性而成为研究热点。本文旨在将当前的影像学相关的帕金森病前驱症状生物学标志研究进展做一综述。
Abstract: REM sleep behaveour disorder (RBD) is a complex behavior disorder associated with dreams that occur during rapid eye movement (REM). Idiopathic RBD (iRBD) is closely related to neurodegen-eration such as Parkinson’s disease, Louis dementia, multiple atrophy systems and so on. Among of them, Parkinson’s disease is the most common. iRBD is a precursor to neurodegeneration. It’s par-ticularly important to discover and intervene in neurodegeneration early. Many studies have fo-cused on the biomarkers of RBD-related neurodegeneration, in which imaging techniques have become a hot topic for their objectivity and rapid progress. The aim of this paper is to review the recent advances in imaging-related Parkinson’s disease precursor biomarkers.
文章引用：黄雅琴, 张轩, 马莉, 薛蓉. 快速眼动睡眠期行为障碍相关的帕金森病的影像学生物标志研究进展[J]. 国际神经精神科学杂志, 2020, 9(2): 13-19. https://doi.org/10.12677/IJPN.2020.92002

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