脑动脉瘤介入栓塞术治疗前后不同血管壁厚度患者的TNF-α和IL-6表达及其作用机制

Expressionand Mechanism of TNF-α and IL-6 in Patients with Different Vascular WallThickness before and after Cerebral Aneurysm Embolization

摘要: 目的：探讨脑动脉瘤介入栓塞术治疗前后不同血管壁厚度患者的TNF-α和IL-6表达及其作用机制。方法：将2016年1月至2019年1月期间在我院行脑动脉瘤介入栓塞术的80例内动脉瘤患者作为观察组研究对象，并选取同期于我院80例接受脑内血肿清除、内减压术及被证实为非血管性疾病的患者作为对照组，分别对两组患者治疗前后的TNF-α和IL-6表达情况进行比较。同时，观察组患者根据血管壁厚度分为增厚组和非增厚组，各40例，评定两组间TNF-α肿瘤坏死因子(TNF)-α和白细胞介素(IL)-6表达水平，以及其和患者生活质量的相关性分析。结果：经比较，观察组治疗前的TNF-α和IL-6表达水平明显更高于对照组和治疗后，差异显著(P < 0.05)，治疗后，观察组与对照组间的TNF-α和IL-6表达水平比较差异不显著(P > 0.05)；非增厚组患者的TNF-α和IL-6表达水平相较于增厚组更低，差异显著(P < 0.05)；另外，TNF-α和IL-6表达水平呈现正相关，而两者与生活质量显著负相关(P < 0.05)。结论：脑动脉瘤患者血清中TNF-α和IL-6表达水平异常上升可能和脑动脉瘤生成和破裂相关，检测患者脑血管的TNF-α和IL-6水平可以有助于评估患者的疾病情况和预后。

Abstract: Objective: To investigate the expression and mechanism of TNF-α and il-6 in patients with different vascular wall thickness before and after cerebral aneurysm embolization. Methods: 80 patients with intracranial aneurysm who underwent interventional embolization of cerebral aneurysm in our hospital from January 2016 to January 2019 were selected as the study subjects in the observation group, and 80 patients who received intracranial hematoma clearance, internal de-compression and confirmed non-vascular disease in our hospital during the same period were se-lected as the control group. TNF-α and il-6 expression before and after treatment were compared between the two groups. At the same time, patients in the observation group were divided into the thickening group and the non-thickening group according to the thickness of the vascular wall, with 40 cases in each group, and the expression levels of TNF-α and interleukin (il-6) between the two groups were evaluated, as well as the correlation analysis between them and the quality of life of patients. Results: The expression levels of TNF-α and il-6 in the observation group before treatment were significantly higher than those in the control group after treatment (P < 0.05), while the expression levels of TNF-α and il-6 between the observation group and the control group were not significantly different after treatment (P > 0.05). The expression levels of TNF-α and il-6 in the non-thickening group were lower than those in the thickening group (P < 0.05). In addition, the expression levels of TNF-α and il-6 were positively correlated, while both were significantly negatively correlated with the quality of life (P < 0.05). Conclusion: Abnormal increase of TNF-α and il-6 expression levels in serum of patients with cerebral aneurysm may be related to the formation and rupture of cerebral aneurysm, and the detection of TNF-α and il-6 levels in cerebral vessels of patients can help to assess the disease status and prognosis of patients.